| 溴氰菊酯对大鼠脑组织G蛋白转换的影响 |
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| 引用本文： | 严红,刘烈刚,石年,刘毓谷. 溴氰菊酯对大鼠脑组织G蛋白转换的影响[J]. 中国公共卫生, 2003, 19(1): 19-20 |
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| 作者姓名： | 严红 刘烈刚 石年 刘毓谷 |
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| 作者单位： | 华中科技大学同济医学院卫生毒理学系,武汉,430030 |
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| 摘 要： | 目的 研究溴氰菊酯对大鼠脑组织中G蛋白在活性状态和非活性状态之间转换的影响。方法 雄性SD大鼠经溴氰菊酯腹腔注射处理，用Westernblot方法检测大鼠脑中GAP的含量，用酶学方法检测大鼠脑NDK的活性。结果 溴氰菊酯可以增加大鼠脑组织中GAP的含量，升高NDK活性。结论 溴氰菊酯具有加速G蛋白转换过程的作用。
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| 关 键 词： | 溴氰菊酯 G蛋白 G蛋白转换 毒理学 |
| 文章编号： | 1001-0580(2003)01-0019-02 |
| 修稿时间： | 2002-02-27 |
Effect of deltamethrin on G protein turnover in rat''''s brain |
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| YAN Hong,LIU Lie gang,SHI Nian,et al.. Effect of deltamethrin on G protein turnover in rat''''s brain[J]. Chinese Journal of Public Health, 2003, 19(1): 19-20 |
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| Authors: | YAN Hong LIU Lie gang SHI Nian et al. |
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| Affiliation: | YAN Hong,LIU Lie gang,SHI Nian,et al.Department of Public Toxicology,Tongji Medical College of Huazhong University of Science and Technology |
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| Abstract: | Objective To study the effect of deltamethrin on G protein turnover in rat brain.Methods Male SD rats were treated by deltamethrin ip,the content of GAP was detected by western blot technology,the activity of NDK was determined by radiolabeled methodology.Results Content of GAP and activity of NDK could be enhanced by DM.Conclusion The turnover of G protein could be accelerated by DM. |
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| Keywords: | pesticide deltamethrin G protein G protein turnover |
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