单纯型糖尿病视网膜病变黄斑无血管区与视力

探讨了单纯型糖尿病视网膜病变(non—Prolifcrative diabtie retinopathy,NDR)患者视力与视网膜黄斑无血管区(foveal avascular zone,FAZ)大小的关系.应用微机图像处理系统,测算43只NDR患眼和20只正常眼眼底荧光血管造影负片上FAZ与视盘的面积比值.NDR视力正常组和正常对照间该比值无显著差异(P>0.05).在NDR视力下降组中,该比值显著大于上述两组(P<0.01)、且与患者视力呈显著切相关(P<0.001),其糖尿病程亦较NDR视力正常组长(P<0.05).结论:NDR患者糖尿病病程较长时,FAZ与视盘的面积比值增大到一定程度,将引起视力损害,且损害随该比值的增大而加重.

The Relationship of Foveal Avascular Zone to Visual Acuity in Non-proliferative Diabetic Retinopathy

PURPOSE: To assess the relationship of the foveal avascular zone (FAZ) to visual acuity in Chinese Patients with non-proliferative diabetic retinopathy (NDR) of non-insulin dependent diabetes mellitus (NIDDM). METHODS: Fundus fluorescein angiograms (FFA) of 43 eyes with NDR and 20 normal control eyes were studied by cmputerzed image analysis system, and the area ratio of the FAZ to the optic disc was calculated. RESULTS: Quantitatively, the ratio was significantly greater in the NDR group with reduced visual acuity, compared with both the NDR group with unaffected visual acuity and the control group (P<0.01), whereas, the ratio was not different among the later two groups (P<0.05). In the NDR group with reduced visual acuity, the ratio was highly correlated with visual acuity (P<0.001), and it's coures of NIDDM was longer than the other NDR group (P<0.05). CONCLUSIONS: the data indicated that, in NDR after some period of NIDDM, once the ratio reached the critical value, visual acuity would be affected, and could decline more as the ratio got greater.