Intravesicular taxane‐induced dermatotoxicity in a 78‐year‐old man with urothelial carcinoma and primary cutaneous anaplastic large cell lymphoma |
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Authors: | Daniel J Pelletier Michael O'Donnell Mary Seabury Stone Vincent Liu |
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Institution: | 1. Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa;2. Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa;3. Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa |
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Abstract: | Patients treated with intravesical bacillus Calmette‐Guérin therapy for urothelial carcinoma often become refractory and experience recurrent disease, thus necessitating alternative intravesical treatment modalities if the patient is to be spared the morbidities associated with radical cystectomy. Intravesical treatment with taxane‐based chemotherapy, such as docetaxel, has gained traction in urologic oncology, proving to be an effective salvage therapy in such patients. Systemic taxane‐based chemotherapeutic regimens have long been used in several advanced malignancies, and their systemic side‐effects and associated histologic correlates have been extensively documented. In contrast to adverse effects associated with systemic administration, intravesical taxane administration has thus far proven to be well‐tolerated, with little to no systemic absorption. To our knowledge, features of taxane‐induced systemic effects have not been reported in this setting. Herein, we report a case of a patient with recurrent urothelial carcinoma treated with intravesical docetaxel, along with primary cutaneous anaplastic large cell lymphoma, who developed characteristic dermatotoxic histologic findings associated with intravenous taxane administration. As such histopathologic findings often represent close mimickers of neoplastic and infectious etiologies, knowledge of the potential for systemic manifestations of taxane therapy in patients treated topically may prevent potentially costly diagnostic pitfalls. |
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Keywords: | chemotherapy dermatotoxic taxane toxicity urothelial carcinoma |
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