Pleomorphic fibroma of the skin with MDM2 immunoreactivity: A potential diagnostic pitfall |
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Authors: | Mehrnoosh Tashakori Jason Pimentel Brooke E Howitt Jessica Sanchez Susan Michalowski Dhananjay Chitale Adrian H Ormsby Sean R Williamson |
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Institution: | 1. Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan;2. Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts;3. Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan |
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Abstract: | Pleomorphic fibroma is a rare benign cutaneous neoplasm characterized by spindle‐shaped cells and multinucleated giant cells scattered throughout collagenous stroma. These morphologic features can lead to diagnostic confusion, including atypical lipomatous tumor as one consideration. In contrast to atypical lipomatous tumor, previous studies have found pleomorphic fibroma to be negative for MDM2 immunohistochemical staining and MDM2 gene amplification. Here, we present a case of pleomorphic fibroma of skin with nuclear MDM2 immunoreactivity in the absence of MDM2 gene amplification, underscoring the superiority of fluorescence in situ hybridization as a diagnostic test in this differential diagnosis. The RB1 locus is also explored for differential diagnosis with pleomorphic/spindle cell lipoma and related entities. |
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Keywords: | fluorescence in situ hybridization immunohistochemistry MDM2 pleomorphic fibroma |
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