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A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress
Authors:Sebastian Thams  Emily Rhodes Lowry  Marie-Hélène Larraufie  Krista J. Spiller  Hai Li  Damian J. Williams  Phuong Hoang  Elise Jiang  Luis A. Williams  Jackson Sandoe  Kevin Eggan  Ivo Lieberam  Kevin C. Kanning  Brent R. Stockwell  Christopher E. Henderson  Hynek Wichterle
Affiliation:1. Department of Pathology and Cell Biology, Center for Motor Neuron Biology and Disease, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA;2. Department of Biological Sciences and Department of Chemistry, Columbia University, Northwest Corner Building, MC4846, 550 West 120th Street, New York, NY 10027, USA;3. Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, 650 West 168th Street, New York, NY, USA;4. Department of Stem Cell and Regenerative Biology, Harvard University, MA 02138, USA;5. Centre for Stem Cells and Regenerative Medicine and MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1 9RT, UK;6. Departments of Neuroscience, Rehabilitation and Regenerative Medicine, and Neurology, Columbia University Irving Medical Center, 630 West 168th Street, New York, NY 10032, USA
Abstract:
Keywords:motor neuron  stem cell  ER stress  ALS  cyclopiazonic acid
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