| Affiliation: | 1. Service de Transplantation, Néphrologie et Immunologie Clinique, Hospices Civils de Lyon, H?pital Edouard Herriot, , Lyon, France;2. Service d'Hépatologie, Gastroentérologie et Nutrition, Hospices Civils de Lyon, H?pital Femme Mère Enfant, , Bron, France;3. Laboratoire d'anatomopathologie, Hospices Civils de Lyon, H?pital Edouard Herriot, , Lyon, France;4. Service d'Anatomie et Cytologie Pathologiques, Hospices Civils de Lyon, Groupement Hospitalier Est, , Bron, France;5. Département d'oncologie médicale, Centre Leon Bérard, , Lyon, France;6. Service de chirurgie maxillo‐faciale et stomatologie, CHU d'Amiens, , Amiens, France;7. Faculté de médecine Lyon Est, Université de Lyon, , Lyon, France |
| Abstract: | Epstein–Barr virus (EBV) is known to establish latent infections in B‐lymphocytes that can cause lymphoproliferative disorders particularly in immunocompromised patients. More recently, the development of rare EBV‐associated smooth muscle tumors has been reported in transplant recipients. We herein describe 2 new cases of EBV‐associated post‐transplant smooth muscle tumors (EBV‐PTSMT), including the first in a facial composite tissue graft recipient. Among the striking features shared by these 2 patients were their young ages, the fact that they were naïve for EBV before the transplantation, that they developed a post‐transplant lymphoproliferative disorder before the diagnosis of EBV‐PTSMT, and that they responded favorably to reduction of immunosuppression. Radiological and histologic features of EBV‐PTSMT are shown. Finally, pathophysiology and therapeutic management of EBV‐PTSMT are discussed based on a comprehensive review of the literature. |
