微小染色体维持蛋白2在乳腺癌组织中的表达及意义

目的:探讨微小染色体维持蛋白2(MCM2p)在乳腺癌的表达及其与临床病理特征的关系,并分析MCM2p与Ki-67的相关性。方法:运用免疫组织化学方法检测乳腺癌组织中MCM2p、Ki-67的表达。结果:在乳腺癌组织中MCM2p、Ki-67的表达均高于正常乳腺组织,且MCM2p的标记指数明显高于Ki-67,两者表达呈正相关。MCM2p的表达与肿瘤的分化程度、淋巴结转移、临床病理分期和核分裂指数有非常显著相关性,与患者的年龄、肿瘤大小及组织学类型无显著性关系。结论:MCM2p与乳腺癌临床病理的发展紧密相关,作为病理诊断的参考指标较Ki-67有更强的敏感性。

Expression of minichromosome maintenance protein 2 in breast cancer and its significance

Objective: To study the relationship between minichromosome maintenance protein 2(MCM2p) expression and clinical pathological characteristics of breast cancer,and to analyze the correlation between MCM2p and Ki-67.Methods:The expression of MCM2p and Ki-67 was examined in breast cancer tissue and normal tissues with immunohistochemistry.Results: The expression of MCM2p and Ki-67 was both higher in cancer than those in normal tissues,and the labeling index of MCM2p was higher than that of Ki-67.A positive relationship was found between MCM2p and Ki-67.Labeling index of MCM2p showed significant correlation with the differentiation degree,lymph node status,pathologic stage and mitotic index,but not with patient age,tumor size and histological types.Conclusion: MCM2p has a close correlation with clinic pathological progress of breast cancer and is more sensitive than Ki-67 as an indicator for pathological diagnosis of breast cancer.