血清同型半胱氨酸、血脂水平与冠心病关系研究

目的：探讨血清同型半胱氨酸（Hcy）及血脂水平与冠状动脉粥样硬化性心脏病（CHD）之间的关系。方法选择2013年1月至2014年4月在该院心内科住院的204例CHD患者为CHD组，其中中青年（36～＜60岁）87例，老年（60～88岁）117例；同时选择在该院健康体检者122例为对照组，其中中青年（39～＜60岁）52例，老年（60～83岁）70例。分别检测两组受试者血清Hcy水平，三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白AⅠ（apoAⅠ）、apoB、脂蛋白（a）Lp（a）]水平，并进行比较与分析。结果两组老年Hcy水平显著高于中青年，且CHD组不同年龄的Hcy水平显著高于对照组，差异均有统计学意义（P＜0.05）；CHD组患者的Hcy、TG、Lp（a）水平显著高于对照组，apo AⅠ水平显著低于对照组，差异均有统计学意义（P＜0.05），而两组之间TC、HDL-C、LDL-C、apoB水平比较，差异均无统计学意义（P＞0.05）。结论 Hcy水平与年龄有关，是CHD的独立危险因子，其与血脂指标联合检测，对CHD患者的诊断、治疗及预后具有重要临床意义。

Relationship between homocysteine,blood lipid and coronary heart disease

Objective To explore the relationship between levels of serum homocysteine （Hcy）,blood lipid and coronary heart disease （CHD）. Methods A total of 204 patients with coronary heart disease patients was selceted as the CHD group ,in-cluding 87 young and middle-aged patients（36-＜60 years old） and 117 aged patients（60-88 years old）,meanwhile,another 122 healthy people were deem as the control group including 52 youths （39-60 years old） and the middle-aged and 70 aged people （60-83 years old）, the levels of Hcy TG,TC,HDL-C,LDL-C,apoAⅠ,apoB,Lp（a） of the two groups were detected and com-pared. Results Hcy levels of the two aged groups were significantly higher than that of the young and middle-aged. Hcy level in different ages in CHD group was significantly higher than that of the control group （P＜0.05）. Hcy,TG,Lp（a） were significantly high-er than those of the control group,while apoAⅠwas significantly lower than the control group （P＜0.05）. TC,HDL-C,LDL-C and apo B levels between the two groups had no significant difference（P＞0.05）. Conclusions Hcy level is associated with age,who is one of independent risk factors for coronary heart disease;meanwhile,the combined inspection of CHD and blood lipids is bene-fit for the diagnosis,treatment and prognosis of great clinical significance.