轻度认知障碍及阿尔茨海默病患者甲状腺功能的变化

目的探讨轻度认知功能障碍及阿尔茨海默病患者甲状腺功能的变化。方法用放射免疫法检测轻度认知功能障碍（mildc ognition impairment,MCI）、阿尔茨海默病（Alzheimer＇s disease,AD）组,及正常老年人组三碘甲状腺原氨酸（triiodo-thyronine,T3）、T4甲状腺素（tetraiodothyronine,T4）、游离三碘甲状腺原氨酸（free triiodothyronine,FT3）、FT4游离甲状腺素（free thyroxine,FT4）、促甲状腺激素（thyrotropin,TSH）水平。结果MCI患者T3的水平明显降低〔（0.51±0.14）μg/L〕,AD患者T3的水平明显降低〔（0.54±0.11）μg/L〕,与对照组〔（0.74±0.17）μg/L〕比较,差异有统计学意义（均P〈0.01）;MCI及AD患者的FT3水平也明显降低〔（1.62±0.34）pmol/L,（1.55±0.32）pmol/L〕,与对照组〔（1.94±0.46）pmol/L〕比较,差异有统计学意义（均P〈0.01）;与对照组TSH〔（2.94±2.12）mU/L〕比较,MCI患者TSH水平〔（2.62±1.98）mU/L〕无明显变化（P〉0.05）,AD患者TSH水平明显降低〔（1.54±0.88）mU/L〕（P〈0.01）。结论MCI及AD患者甲状腺功能降低,TSH在MCI向AD的转变过程中可能有临床参考价值。

Alterations of Thyroid Function in Patients with Mild Cognition Impairment and Alzheimer Dsease

Objective]To explore the alterations of thyroid function in patients with mild cognition impairment and Alzheimer disease.Methods]The levels of serum triiodothyronine（T3）,tetraiodothyronine（T4）,firee triiodothyronine（FT3）,free thvroxine（FT4）,and thvrotroDin（TSH） were measured by radioimmunoassay in mild cognition impairment（MCI） group,Alzheimer disease （AD） group,and normal elderly group.Results]The levels of T3 significantly decreased in MCI group 〔（0.51±0.14） μg/L〕,and that of AD group also decreased obviously〔（0.54±0.11） μg/L〕,comparing with the control group 〔（0.74±0.17） μg/L〕,the difference was significant （both P0.01）.The levels of FT3 decreased in MCI group and AD group 〔（1.62±0.34） pmol/L,（1.55±0.32）pmol/L〕 as compared with control group 〔（1.94±0.46 pmol/L〕,the difference was significant （both P0.01）;compared with controls〔（2.94±2.12） mU/L〕,the level of TSH in MCI group 〔（2.62±1.98） mU/L〕 did not change significantly （P0.05）,while the level of TSH in AD group〔（1.54±0.88 ）mU/L〕 decreased significantly （P0.01）.Conclusion]Thyroid function reduces in MCI and AD patients,the TSH level implies a possible clinical value in MCI to AD transformation.