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| KA致痫大鼠脑组织中N-cadherin mRNA的表达及意义 | |
| 引用本文： | 寇玉红,张淑琴,林卫红,孟红梅,包雪鹦,王赞. KA致痫大鼠脑组织中N-cadherin mRNA的表达及意义[J]. 中风与神经疾病杂志, 2005, 22(6): 538-539 |
| 作者姓名： | 寇玉红 张淑琴 林卫红 孟红梅 包雪鹦 王赞 |
| 作者单位： | 1. 吉林市中心医院神经内科,吉林,吉林,132001 2. 吉林大学第一医院神经内科,吉林,长春,130021 3. 中国人民解放军208医院神经内科,吉林,长春,130003 |
| 摘 要： | 目的探讨癫痫鼠脑组织中N-cadherin mRNA的表达及意义。方法通过原位杂交方法对KA致痫鼠脑组织中N-cadherin mRNA的表达进行检测。结果对照组、手术对照组颞叶及海马均可见明显的N-cadherin mRNA的表达，但海马区明显高于颞叶。在充分点燃后12h，N-cadherin mRNA的表达明显下降，CA3区下降的最早且明显，在点燃后7d逐渐恢复，在14d时接近正常值，在28d高于对照组、手术对照组。结论N-cadherin是突触重建的重要的调控因子，是新的突触形成的介质，在癫痫的发生、发展中起着重要的调控作用。 |
| 关 键 词： | 癫痫 N-cadherin mRNA 原位杂交 |
| 文章编号： | 1003-2754（2005）06-0538-02 |
| 收稿时间： | 2005-06-20 |
| 修稿时间： | 2005-11-16 |
The expression of N-cadherin mRNA in the brain tissue of epilepsy-rat induced by KA |
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| KOU Yu-hong,ZHANG Shu-qin ,LIN Wei-hong ,et al. The expression of N-cadherin mRNA in the brain tissue of epilepsy-rat induced by KA[J]. Journal of Apoplexy and Nervous Diseases, 2005, 22(6): 538-539 | |
| Authors: | KOU Yu-hong ZHANG Shu-qin LIN Wei-hong et al |
| Abstract: | Objective To study the relationship between N-cadherin mRNA and epilepsy. Method The expression of N-cadherin mRNA was detected in different brain regions and different periods by in situ hybridization. Result Compared to the control group,the expression of N-cadherin mRNA decrease at 12h following kindling. With the development of the seizure ,N-cadherin mRNA began to recover at 14d and exceeded the normal level obviously at 28d. Conclusion N-cadherin plays an important role in the recurring of seizure,which is a key modulator of synaptic reconstruction. |
| Keywords: | Epilepsy N-cadherin mRNA In situ hybridization |
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