Carcinohistogenesis and expression of alpha fetoprotein in experimental hepatocarcinoma |
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Authors: | Jizeng Zhang |
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Institution: | (1) Department of Pathology, General Hospital, Lanzhou Military Command, PLA, No. 58, Xiao-Xi--Hu West Road, Qi-Li-He District, 730050 Lanzhou, China |
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Abstract: | Subjective: The purpose of investigating the carcinohistogenesis of hepatocarcinoma and alpha-fetoprotein AFP expression in
oncogenesis was to lay a morphological foundation for diagnosing and curing hepatocarcinoma. Methods: Experimental hepato
carcinoma of Wistar rats induced by 0.04% 3′-Me-DAB and killed according to different dates. All the animals were killed during
a period of 36 weeks. The morphologic changes of dynamics and expression of (AFP) with immunohistochemical method were observed.
Results: Hyperplasia of oval cells was multipotento-differential stem cell. It was further differentiated into transitional
cell and embryoid small liver cell, and the latter can form pattern of atypical hyperplasia, which scattered or crowded. The
AFP in these cells showed was a strong positive expression. The feature was different between crowded small hepatocytes of
atypical hyperplasia and proliferative nodules of hepatocytes. The former was similar to morphologic character of liver cell
carcinoma. The oval cells were toward biliary duct differentiation to form fibroadenomatoid structure, and atypical hyperplasia
was also seen in their epithelial cells. Of all the 58 experimental animals there were 26 with hepatocarcinoma, among which
18 cases of hepatocytic carcinoma and 8 mixed carcinoma were found. The hepatocellular carcinoma showed AFP strong positive
expression In the host hestocytes around cancer and hepatocytes of non-neoplastic animals of a later experimental period also
expressed various degrees of AFP positive. Conclusion: Atypical hyperplasia of small hepatocytes and epithelial cells of bile
canaliculi were the precancerous lesions of hepatocellular carcinoma and bile duct carcinoma. |
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Keywords: | Hepatocarcinoma Hyperplasia Alphafetoprotein Precancerous lesion |
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