复方丹蒲汤抗实验性胃溃疡的作用

目的:研究复方丹蒲汤(丹参、蒲公英、砂仁等)抗实验性胃溃疡的作用及其机制。方法:采用小鼠水浸应激性、利血平性、无水乙醇性、幽门结扎性胃溃疡模型观察复方丹蒲汤对胃溃疡的保护作用及对大鼠胃液分泌的影响;采用小鼠胃排空方法观察复方丹蒲汤对胃运动的影响;以热板法观察其镇痛作用。结果:复方丹蒲汤对小鼠水浸应激性、利血平性及无水乙醇性胃溃疡模型均有明显的保护作用;能抑制大鼠胃酸及胃蛋白酶的分泌,降低大鼠胃溃疡指数,减少溃疡面积;抑制小鼠胃排空;延长小鼠热刺激的痛反应时。结论:复方丹蒲汤具有抗实验性胃溃疡的作用。该作用可能与其抑制胃液分泌、胃平滑肌运动及镇痛作用有关。

Action of Fufang Danpu Decoction on experimental gastric ulcer

AIM: To study the action of Fufang Danpu Decoction(FFDPD) on experimental gastric ulcer in mice. METHODS: The anti-gastric ulcer action of FFDPD was observed on the gastric ulcer induced by water immersion stress,absolute ethyl alcohol,reserpine and pyloric ligation.The effect on gastric secretion in rats was studied by pyloric ligation.The effect on gastrointestinal motility was observed by gastric emptying in mice. The analgesic effect was tested by the hot-plate test. RESULTS: FFDPD markedly inhibited gastric ulcer induced by water immersion stress,absolute ethyl alcohol,reserpine and pyloric ligation.FFDPD significantly inhibited the secretion of gastric acid and pipsin.FFDPD markedly delayed gastric emptying and enhanced hot pain threshold in mice. CONCLUSION: FFDPD may have anti-gastric ulcer effect,in relation to its inhibition of the secretion of gastric juice,of activity of gastric smooth muscle and analgetic effect.