| 阿莫西林与舒巴坦配伍稳定性影响因素分析体会 |
| |
| 引用本文： | 陈旭照,徐一君,向金生. 阿莫西林与舒巴坦配伍稳定性影响因素分析体会[J]. 实用医技杂志, 2006, 13(18): 3155-3157 |
| |
| 作者姓名： | 陈旭照 徐一君 向金生 |
| |
| 作者单位： | 无锡市第四人民医院,江苏,无锡,214062 |
| |
| 摘 要： | 目的:考察注射用阿莫西林/舒巴坦在3种液体中的稳定性,为临床合理使用药物提供依据。方法:选择4℃、25℃、37℃,在3h内观察配伍液外观、pH值变化,并用RP-HPLC法测定阿莫西林与舒巴坦的含量。结果:稳定性和光照、温度和溶媒有关,在NS中较为稳定。结论:注射用阿莫西林/舒巴坦在葡萄糖注射液(GS)中较为稳定,宜选用GS为溶媒。
|
| 关 键 词： | 阿莫西林/舒巴坦 稳定性 RP-HPLC |
| 文章编号： | 1671-5098（2006）18-3155-03 |
| 收稿时间： | 2006-06-07 |
Compatible Stability of Amoxicillin/ Sulbactam Sodium for Injection in Three Kinds Infusion Solutions |
| |
| CHEN Xu-zhao,XU Yi-jun,XIANG Jin-sheng. Compatible Stability of Amoxicillin/ Sulbactam Sodium for Injection in Three Kinds Infusion Solutions[J]. Journal of Practical Medical Techniques, 2006, 13(18): 3155-3157 |
| |
| Authors: | CHEN Xu-zhao XU Yi-jun XIANG Jin-sheng |
| |
| Abstract: | Objective To study the compatible stability of Amoxicillin/ Sulbactam in three kinds infusion solutions with RP-HPLC method so as to offer a scientific basis for rational use of drug in clinical practice. Method The external appearance and PH values of the mixed solution were observed, and the contents of Amoxicillin and Sulbactam were determined by RP-HPLC method at 4 ℃、25 ℃、37 ℃ for 3 hours. Results The stability was related to temperature ,time and different kinds infusion solutions. Conclusion The stability of Amoxicillin/ Sulbactam Sodium is highest in NS, so the best infusion solution is NS. |
| |
| Keywords: | Amoxicillin/sulbactam Stability RP-HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
