| 异佛尔酮二导氰酸酯致畸致突变性研究 |
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| 引用本文： | 杨磊,蒋芸,张招弟,彭德慧. 异佛尔酮二导氰酸酯致畸致突变性研究[J]. 农垦医学, 1991, 0(4) |
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| 作者姓名： | 杨磊 蒋芸 张招弟 彭德慧 |
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| 作者单位： | 石河子医学院公共卫生教研室，同济医科大学工业毒理室，同济医科大学工业毒理室，同济医科大学工业毒理室 |
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| 摘 要： | 大鼠致畸试验显示,IPDI 对胎鼠的生长发育具有明显的抑制作用并造成胚胎的早期死亡,但无致畸胎作用。致畸系数小于8。体外染色体畸变试验表明:IPDI 具有断裂剂活性并可直接作用于纺锤体。对接触 IPDI 工人染色体的畸变分折未发现相似结果。也未发现 IPDI 对接触工人的遗传、生殖有明显影响。
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| 关 键 词： | 致畸胎性 发育毒性 致突变性 |
ASSESMENT OF TARATOGENICITY AND MUTAGENICITY CALLEDBY ISOPHORONE DIISOCYANATE(IPDI) |
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| Yang Lei. ASSESMENT OF TARATOGENICITY AND MUTAGENICITY CALLEDBY ISOPHORONE DIISOCYANATE(IPDI)[J]. Agricultural Reclamation Medicine, 1991, 0(4) |
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| Authors: | Yang Lei |
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| Abstract: | The teratogenic experimgnt on wistar rats showed that IPDI hadn't teratogenic effect but had bvioustoxicity.lt could inhibit fetal development and cause intrauterine death.Chromosome aberration experiment in vitro demonstrated that the rate of aberration cells is signi- ficantly higher then that of blank control group,when IPDI concentration is above 320ug/ml.But the same effect could'nt be found between the 19 IPDI workers and 7 controls.No obvious genetis and reproductive effect were found among IPDI workers. |
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| Keywords: | mutagenicity test teratogens |
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