| 尿激酶型纤溶酶原激活剂在髓母细胞瘤中的表达及意义 |
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| 引用本文： | 王勇,张尚福,等.尿激酶型纤溶酶原激活剂在髓母细胞瘤中的表达及意义[J].华西医科大学学报,2001,32(3):376-378. |
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| 作者姓名： | 王勇 张尚福 |
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| 作者单位： | [1]华西医科大学附属第一医院神经外科，成都610041 [2]附属第一医院病理科 |
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| 摘 要： | 目的 研究尿激酶型纤溶酶原激活剂（uPA）在髓母细胞瘤中的表达及临床意义。方法 应用免疫组化LSAB法检测50例髓母细胞瘤中uPA的表达，结合临床随访，使用Cox回归分析。结果 uPA染色定位于肿瘤细胞和血管内皮细胞。Cox回归分析显示uPA是影响生存时间的一个独立的预后因子，它与预后存在一定的负相关关系。结论 uPA可能是预测髓母细胞瘤预后的一个独立的预后因子。
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| 关 键 词： | 髓母细胞瘤 尿激酶型纤溶酶原激活剂 免疫组织化学 预后 |
Expression and significance of urokinase-type plasminogen activator in medulloblastoma] |
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| Y Wang,B Mao,S Zhang,H Cheng.Expression and significance of urokinase-type plasminogen activator in medulloblastoma][J].Journal of West China University of Medical Sciences,2001,32(3):376-378. |
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| Authors: | Y Wang B Mao S Zhang H Cheng |
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| Affiliation: | Department of Neurosurgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China. |
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| Abstract: | OBJECTIVE: To detect the expression and evaluate the clinical significance of urokinase-type plasminogen activator (uPA) in medulloblastoma. METHODS: LSAB (labelled streptavidin biotin method) immunohistochemical technique was applied for detecting the expression of uPA in 50 patients with medulloblastoma, and a follow-up survey with Cox regression analysis was made. RESULTS: The staining for uPA was localized on tumor cells and endothelial cells. Cox regression analysis showed that uPA was an independent prognostic factor affecting survival and it had a negative correlation with the prognosis. CONCLUSION: uPA appears to be an independent marker for predicting the prognosis of medulloblastoma. |
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