| 沙门氏菌毒力岛及Ⅲ型分泌系统研究进展 |
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| 引用本文： | 陈俊,蒋文灿,谭天,许凯迪,杨丽红. 沙门氏菌毒力岛及Ⅲ型分泌系统研究进展[J]. 中国人兽共患病杂志, 2015, 31(4): 371-376. DOI: 10.3969/cjz.j.issn.1002-2694.2015.04.017 |
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| 作者姓名： | 陈俊 蒋文灿 谭天 许凯迪 杨丽红 |
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| 作者单位： | 1.四川农业大学动物医学院,雅安 625014;#br#2.动物疫病与人类健康四川省重点实验室,雅安 625014 |
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| 基金项目： | 教育部长江学者和创新团队发展计划创新团队项目(IRT0848) |
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| 摘 要： | 沙门氏菌(Salmonella)是寄生于人和动物肠道内的革兰氏阴性杆菌,能引起人和动物多种不同临床症状表现,为人类食物中毒主要病原菌之一。沙门氏菌的侵袭力与毒力岛(pathogenicity island,PI)及其编码的Ⅲ型分泌系统(Type Ⅲ secretion system,T3SS)直接相关。本文对沙门氏菌毒力岛、T3SS组成、T3SS分泌及调控机制、T3SS与沙门氏菌致病性、应用研究等进行综述,以期为深入研究提供参考。
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| 关 键 词： | 沙门氏菌 毒力岛 Ⅲ型分泌系统 T3SS |
| 收稿时间： | 2014-07-10 |
Salmonella pathogenicity island and type III secretion system |
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| CHEN Jun,JIANG Wen-can,TAN Tian,XU Kai-di,YANG Li-hong. Salmonella pathogenicity island and type III secretion system[J]. Chinese Journal of Zoonoses, 2015, 31(4): 371-376. DOI: 10.3969/cjz.j.issn.1002-2694.2015.04.017 |
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| Authors: | CHEN Jun JIANG Wen-can TAN Tian XU Kai-di YANG Li-hong |
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| Affiliation: | 1.Animal Medicine College, Sichuan Agricultural University, Ya'an 625014, China;#br#2.Sichuan Key Laboratory of Animal Disease and Human Health, Ya'an 625014, China |
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| Abstract: | Salmonella was a gram-negative bacterium which parasitized in the intestinal of humans and animals, which could cause a variety of different clinical symptoms in human and animals, and being one of the main pathogens for human food toxicosis. The invasiveness of Salmonella was directly related to pathogenicity island (PI) and type Ⅲ secretion system (T3SS) encoded by PI. The research progress of Salmonella pathogenicity island, the composing of T3SS, secretion and regulation mechanisms of T3SS, T3SS and salmonella pathogenicity, and application research was summarized in this paper, and with a view to providing reference for in-depth study. |
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| Keywords: | Salmonella pathogenicity island type III secretion system T3SS |
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