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血浆ProGRP与血清NSE在小细胞肺癌中的诊断价值
引用本文:柳国成,曾荔山,吴秀风. 血浆ProGRP与血清NSE在小细胞肺癌中的诊断价值[J]. 临床合理用药杂志, 2020, 0(7): 23-24
作者姓名:柳国成  曾荔山  吴秀风
作者单位:福建省莆田市第一医院急诊科;福建省莆田市第一医院检验科;福建医科大学附属协和医院检验科
摘    要:目的分析血浆胃泌素释放肽前体(Pro GRP)与血清神经元特异性烯醇化酶(NSE)在小细胞肺癌(SCLC)中的诊断价值。方法收集2016年5月-2018年4月福建省莆田市第一医院呼吸内科住院患者950例,其中,临床病理和免疫组化初次确诊为SCLC患者43例(SCLC组),非小细胞肺癌患者255例(NSCLC组),肺良性疾病患者652例(肺良性疾病组);另选同期健康体检者49例作为对照组。比较各组血浆Pro GRP水平和血清NSE水平,采用受试者工作曲线(ROC)分析两项指标在SCLC中的诊断价值,并比较两项指标联合检测与单独检测诊断SCLC的敏感度。结果SCLC组Pro GRP和NSE水平高于NSCLC组、肺良性疾病组和对照组;广泛期SCLC患者ProGRP和NSE水平高于局限期SCLC患者。ROC曲线下面积AUROCProGRP(0.861)>AUROCNSE(0.755)。ProGRP与NSE联合检测SCLC的敏感度为93.0%(40/43),高于Pro GRP的79.1%(35/43)和NSE的72.1%(31/43),差异均有统计学意义(P<0.05)。结论Pro GRP对SCLC的诊断效能优于NSE,二者联合检测可提高检测敏感度。

关 键 词:小细胞肺癌  胃泌素释放肽前体  神经元特异性烯醇化酶  诊断价值

Diagnostic value of plasma Pro GRP and serum NSE in small cell lung cancer
LIU Guocheng,ZENG Lishan,WUXiufeng. Diagnostic value of plasma Pro GRP and serum NSE in small cell lung cancer[J]. Chinese Journal of Clinical Rational Drug Use, 2020, 0(7): 23-24
Authors:LIU Guocheng  ZENG Lishan  WUXiufeng
Affiliation:(Department of Emergency,The First Hospital of Putian City,Fujian Province,Putian 351100,China;不详)
Abstract:Objective To analyze the diagnostic value of plasma progastrin-releasing peptide(Pro GRP)and serum neuron specific enolase(NSE)in small cell lung cancer.Methods 950 inpatients of respiratory medicine in Department of Respiratory Medicine,The First Hospital of Putian City,Fujian Province from May 2016 to April 2018 were selected,among them,43 patients with SCLC were diagnosed for the first time in clinical pathology and immunohistochemistry(SCLC group),255 patients with non-small cell lung cancer(NSCLC group),and 652 patients with benign pulmonary disease(benign lung disease group);49 patients served as the control group.The levels of plasma Pro GRP and serum NSE were compared in each group,the receiver operating curve(ROC)was used to analyze the diagnostic value of two indexes in SCLC,the sensitivity of the two indicators combined and individual to the detection of SCLC were compared.Results The levels of Pro GRP and NSE in SCLC group were higher than those in NSCLC group,benign lung disease group and control group;The levels of Pro GRP and NSE in patients with extensive SCLC were higher than in patients with limited SCLC.The area under the ROC curve was AUROCProGRP(0.861)>AUROCNSE(0.755).The sensitivity of Pro GRP and NSE in detecting SCLC(93.0%,40/43)was higher than that of Pro GRP(79.1%,35/43)and NSE(72.1%,31/43),and the differences were statistically significant(P<0.05).Conclusion Pro GRP is superior to NSE in the diagnosis of SCLC,the combined detection can improve the detection sensitivity.
Keywords:Small cell lung cancer  Progastrin-releasing peptide  Neuronspecific enolase  Diagnostic value
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