Pulmonary hypertension due to acute respiratory distress
syndrome |
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Authors: | SA ?amendys-Silva LE Santos-Martínez T Pulido E Rivero-Sigarroa JA Baltazar-Torres G Domínguez-Cherit J Sandoval |
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Institution: | 1. Departamento de Terapia Intensiva, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico;2. Departamento de Terapia Intensiva, Instituto Nacional de Cancerología, Mexico City, Mexico;3. Departamento de Cardioneumología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico |
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Abstract: | Our aims were to describe the prevalence of pulmonary hypertension in patients with
acute respiratory distress syndrome (ARDS), to characterize their hemodynamic
cardiopulmonary profiles, and to correlate these parameters with outcome. All
consecutive patients over 16 years of age who were in the intensive care unit with a
diagnosis of ARDS and an in situ pulmonary artery catheter for
hemodynamic monitoring were studied. Pulmonary hypertension was diagnosed when the
mean pulmonary artery pressure was >25 mmHg at rest with a pulmonary artery
occlusion pressure or left atrial pressure <15 mmHg. During the study period, 30
of 402 critically ill patients (7.46%) who were admitted to the ICU fulfilled the
criteria for ARDS. Of the 30 patients with ARDS, 14 met the criteria for pulmonary
hypertension, a prevalence of 46.6% (95% CI; 28-66%). The most common cause of ARDS
was pneumonia (56.3%). The overall mortality was 36.6% and was similar in patients
with and without pulmonary hypertension. Differences in patients'' hemodynamic
profiles were influenced by the presence of pulmonary hypertension. The levels of
positive end-expiratory pressure and peak pressure were higher in patients with
pulmonary hypertension, and the PaCO2 was higher in those who died. The
level of airway pressure seemed to influence the onset of pulmonary hypertension.
Survival was determined by the severity of organ failure at admission to the
intensive care unit. |
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Keywords: | Pulmonary hypertension Acute respiratory distress syndrome Pulmonary artery catheter Intensive care unit |
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