| 钩端螺旋体脂多糖的结构和功能分析 |
| |
| 引用本文： | 夏碧丽,王砚春,郭晓奎,何平,华允芬.钩端螺旋体脂多糖的结构和功能分析[J].中国人兽共患病杂志,2015,31(12):1185-1188. |
| |
| 作者姓名： | 夏碧丽 王砚春 郭晓奎 何平 华允芬 |
| |
| 作者单位： | 1.浙江工业大学药学院,杭州 310014; 2.上海交通大学基础医学院病原生物学教研室,上海 200025 |
| |
| 基金项目： | 国家自然科学基金(No.81471908) |
| |
| 摘 要： | 钩端螺旋体脂多糖(L-LPS)是钩体外膜上的主要成分,由O-抗原特异性多糖、核心寡糖和脂质A 3部分组成。L-LPS是一种重要的毒力因子,在钩体致病性、免疫性及与外部环境的相互作用中扮演着重要的角色。基于LPS结构特征的不同钩体分为不同的血清型。钩端螺旋体的LPS结构研究对于钩体的分子分型及钩体糖-偶联疫苗的开发具有重要意义。本文对L-LPS的结构、O-抗基因簇、生物学活性和钩体病预防方面的研究进展进行简要的综述。
|
| 关 键 词： | 钩端螺旋体 脂多糖 O-抗原簇 疫苗 |
| 收稿时间： | 2015-08-04 |
Stucture and function of leptospiral lipopolysaccharide |
| |
| XIA Bi-li,WANG Yan-chun,GUO Xiao-kui,HE Ping,HUA Yun-fen.Stucture and function of leptospiral lipopolysaccharide[J].Chinese Journal of Zoonoses,2015,31(12):1185-1188. |
| |
| Authors: | XIA Bi-li WANG Yan-chun GUO Xiao-kui HE Ping HUA Yun-fen |
| |
| Institution: | 1.Department of Pharmaceutical, Zhejiang University of Technology, Hangzhou 310012, China; 2.Department of Medical Microbiology and Parasitology, Basic Medical College,Shanghai Jiaotong University, Shanghai 200025, China |
| |
| Abstract: | Leptospiral lipopolysaccharide (L-LPS) is a major component of leptospires outer membrane which consists of three parts, namely O-antigen, core oligosaccharide and lipid A. L-LPS is one of the virulence factors which plays an important role in its pathogenicity, antigenicity, and interacts with external environment. Based on the structural characteristic of LPS, leptospires can be divided into different serotypes. The study of L-LPS structure is important for leptospires molecular typing and Glycan-Conjugate vaccines development. This article gives a brief review on the research progress of L-LPS structure, O-antigen gene cluster, biological activity of L-LPS and L-LPS related vaccine. |
| |
| Keywords: | leptospires lipopolysaccharide O-antigen cluster vaccine |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国人兽共患病杂志》浏览原始摘要信息 |
| 点击此处可从《中国人兽共患病杂志》下载免费的PDF全文 |
|
