肝星状细胞在逆转肝纤维化中的作用

肝纤维化是一种能够导致门静脉高压、肝硬化、肝衰竭的严重疾病。已经发现肝星状细胞的活化是引起肝纤维化的中心环节,因此抑制肝星状细胞的活化、加速肝星状细胞的清除有望逆转肝纤维化。本文将对活化的肝星状细胞的凋亡、衰老以及清除的研究进展作综述,阐明肝星状细胞在肝纤维化过程中所起的作用及相关机制。

Effect of hepatic stellate cells in liver fibrosis regression

Liver fibrosis is considered as a serious disease, which can lead to portal hypertension, liver cirrhosis and liver failure. It has been well established that the activation of hepatic stellate cells plays a vital role in the hepatic fibrosis. Inhibiting hepatic stellate cells activation and accelerating clearance of hepatic stellate cells are promising strategies against liver fibrosis. In this assay, apoptosis, senescence and the clearance of the activated hepatic stellate cells will be reviewed, which aims to demonstrate the effect of hepatic stellate cells and its mechanism in hepatic fibrosis regression.