Clinical outcomes and prognostic factor analysis after salvage surgery for recurrent squamous cell carcinoma of the oral cavity |
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| Affiliation: | 1. Department of Otorhinolaryngology–Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea;2. Department of Otorhinolaryngology–Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, Republic of Korea;1. Department of Plastic and Reconstructive Surgery, First Medical Center, Chinese PLA General Hospital, Beijing, China;2. Center for Applied Clinical Investigation, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA;3. Harvard Medical School, Boston, Massachusetts, USA;4. Harvard School of Dental Medicine, Boston, Massachusetts, USA;1. State Key Laboratory of Military Stomatology and National Clinical Research Centre for Oral Diseases and Shaanxi Clinical Research Centre for Oral Diseases, Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an, China;2. Department of Stomatology, Xi’an Medical University, Xi’an, China;3. Department of Endodontics and Restorative Dentistry, School of Stomatology, Tianjin Medical University, Tianjin, China;4. Department of Health Statistics, School of Preventive Medicine, The Fourth Military, Medical University, Xi’an, China;1. Department of Otolaryngology - Head and Neck Surgery, Regina Elena National Cancer Institute, IRCCS, Via Elio Chianesi 53, Rome, Italy;2. Ear Nose and Throat and Audiology Department, University Hospital of Ferrara, Ferrara, Italy;3. Otorhinolaryngology Unit, Humanitas Clinical and Research Center – IRCCS, Viale Manzoni 56, Rozzano (MI), Italy;4. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele (MI), Italy;5. Department of Radiation Oncology, IRCSS Regina Elena National Cancer Institute, Rome, Italy;1. University Hospital of Besançon, Department of Medical Oncology, France;2. Bregille Reeducation Center, Besançon, France;3. University Hospital of Besançon, Methodology and Quality of Life in Oncology Unit, France;1. Craniofacial Center (CFC), Hirslanden Medical Center, Aarau, Switzerland;2. Department of Oral and Maxillofacial Surgery, Hannover Medical School, Hannover, Germany;3. Brainlab AG, Feldkirchen, Germany;4. Hirslanden Head Office, Zürich, Switzerland;5. Department of Radiotherapy, Hirslanden Medical Center, Aarau, Switzerland;6. Department of Pathology, Hirslanden Medical Center, Aarau, Switzerland;7. Philips AG, Zürich, Switzerland;1. The Royal Melbourne Hospital, Grattan Street, Parkville, Victoria, Australia;2. Melbourne Dental School, Faculty of Medicine Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia |
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| Abstract: | The purpose of this study was to analyze the oncological outcomes and predictive factors for successful curative salvage surgery after recurrent oral cavity squamous cell carcinoma. A retrospective study was conducted involving 73 patients who received surgery-based salvage treatment. The pattern of failure for primary treatment was local failure in 29 patients, regional failure in 29 patients, and loco-regional failure in 15 patients. The 5-year overall, loco-regional failure-free, and disease-free survival rates were 54.8%, 58.9% and 49.3%, respectively. Patients with an advanced initial N stage, previous treatment with combined modality therapy, loco-regional recurrence, advanced recurrent T stage, a disease-free survival of less than 8 months prior to salvage, and recurrence in a previously treated field had a significantly worse prognosis. Given the potential surgical morbidity, salvage surgery should be undertaken after careful consultation with patients who have factors for a poor prognosis. |
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| Keywords: | oral cavity cancer recurrence surgery prognosis mortality |
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