|
|||||
|
|
Mutations of Novel Influenza A(H10N8) Virus in Chicken Eggs and MDCK Cells |
|
| Authors: | Jian Yang Ting Zhang Li Guo Yongfeng Hu Jinlin Li Haoxiang Su Yan Xiao Xianwen Ren Jie Dong Lilian Sun Yan Xiao Li Li Fan Yang Jianwei Wang Hui Yuan Qi Jin |
| Affiliation: | MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J. Yang, T. Zhang, L. Guo, Y. Hu, J. Li, H. Su, Y. Xiao, X. Ren, J. Dong, L. Sun, Y. Xiao, L. Li, F. Yang, J. Wang, Q. Jin); ;Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, China (H. Yuan) |
| Abstract: | The recent emergence of human infection with influenza A(H10N8) virus is an urgent public health concern. Genomic analysis showed that the virus was conserved in chicken eggs but presented substantial adaptive mutations in MDCK cells. Our results provide additional evidence for the avian origin of this influenza virus. |
| Keywords: | influenza A virus mutation genome avian-origin antiviral drug resistance viruses A(H10N8) |