黄斑水肿方治疗痰湿内蕴型中心性浆液性视网膜脉络膜病变

目的：探讨黄斑水肿方对痰湿内蕴型中心性浆液性视网膜脉络膜病变的临床疗效。
　　方法：采用随机对照方法,将56例71眼痰浊内蕴型中心性浆液性视网膜脉络膜病变患者分为对照组28例35眼和治疗组28例36眼。对照组给予复方樟柳碱注射液颞浅动脉旁注射,2 lL/次,1次/d。在上述治疗的基础上,治疗组患者加用黄斑水肿方(泽泻15 g、茯苓20 g、猪苓10 g、白术15 g、桂枝10 g、陈皮10 g、丹参15 g、生黄芪20 g、柴胡10g、半夏8g,10g/次,口服,2次/d)进行干预。3lo后,观察并分析两组患者的总体疗效及视力、视野平均光敏感度和OCT的变化情况。
　　结果：治疗后,治疗组患者的总有效率为89%,显著高于对照组79%(P<0.05)；和对照组比较,治疗组患者的视力和视野平均光敏感度均显著提高(P<0.05)；治疗组患者的黄斑中心区直径1 ll范围的厚度、黄斑中心区直径6 ll的平均厚度和黄斑中心区直径的总体积均显著降低,差异有统计学意义(P<0.05)。
　　结论：黄斑水肿方可显著改善痰湿内蕴型中心性浆液性视网膜脉络膜病变患者的视力、视野,减轻病变区的水肿程度,促进视功能的恢复。

Efficacy of Chinese medicine formula for central serous chorioretinopathy

AIM:To investigate the clinical efficacy of Chinese medicine formula for macular edema in the patients with phlegm intrinsic type and central serous chorioretinopathy(CSCR).

METHODS:With randomized controlled method,56 cases(71 eyes)with phlegm intrinsic type and CSCR were randomly divided into the control group and the treatment group.The control group included 28 cases(35 eyes),and the treatment group 28 cases(36 eyes).The patients in the control group received injections of 2mL compound anisodine beside superficial temporal artery,once a day.Based the above treatment,the patients in the treatment group were given 10g oral Chinese medicine formula for macular edema,twice a day.After 3mo,the overall curative effect,visual acuity,visual field mean sensitivity and the OCT in both groups were measured and evaluated.

RESULTS:After treatment,the total effective rate in treatment group was 89%,which was significantly higher than 79% in the control group(P< 0.05).Compared with the control group,the vision and visual field mean sensitivity in the treatment group significantly increased,and macular center thickness of 1mm diameter range,the average thickness of the macular area of 6mm diameter and the diameter and the central area and the total macular volume were statistically significantly lower(P<0.05).

CONCLUSION:Chinese medicine formula for macular edema may ameliorate the visual acuity and visual field in the patients with phlegm intrinsic type and central serous chorioretinopathy,reducing edema lesions and promoting the recovery of visual function.