| 天然药物化学史话:甾体化合物 |
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| 引用本文： | 郭瑞霞,李力更,王于方,王磊,张嫚丽,詹文红,史清文. 天然药物化学史话:甾体化合物[J]. 中草药, 2016, 47(8): 1251-1264 |
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| 作者姓名： | 郭瑞霞 李力更 王于方 王磊 张嫚丽 詹文红 史清文 |
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| 作者单位： | 石家庄学院化工学院 药物化学教研室, 河北 石家庄 050035;河北医科大学药学院 天然药物化学教研室, 河北 石家庄 050017;河北医科大学药学院 天然药物化学教研室, 河北 石家庄 050017;河北医科大学药学院 天然药物化学教研室, 河北 石家庄 050017;河北医科大学药学院 天然药物化学教研室, 河北 石家庄 050017;河北医科大学药学院 天然药物化学教研室, 河北 石家庄 050017;河北医科大学药学院 天然药物化学教研室, 河北 石家庄 050017;河北医科大学药学院 天然药物化学教研室, 河北 石家庄 050017 |
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| 基金项目： | 河北省中医药管理局科研计划项目(2014071);第54批中国博士后科学基金面上项目(2013M540214);第46批留学回国人员科研启动基金资助项目(王磊);河北省重点课题(ZD2016093);河北省高等教育学会高等教育科学研究课题资助项目(GJXH2013-141);河北医科大学教育科学研究重点课题资助项目(2012yb-19,2014yb-21) |
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| 摘 要： | 甾体化合物是一类重要的天然产物,在人类发展史上不仅为人类的健康做出了特殊的贡献,而且其立体结构的特殊性方面也在有机化学发展史,特别是有机化学理论上占有极其重要的地位,完善了立体化学理论。通过对甾体化合物的发现、生物活性、重要化合物的立体结构以及有机立体化学理论的发展、合成研究等发展历史进行简要介绍,为相关科研人员在教学和科研工作中提供一些启发和思路。
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| 关 键 词： | 甾体化合物 甾体皂苷 甾体激素 立体结构 立体化学 合成 |
| 收稿时间： | 2016-01-20 |
Historical story on natural medicinal chemistry: Steroids |
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| GUO Rui-xi,LI Li-geng,WANG Yu-fang,WANG Lei,ZHANG Man-li,ZHAN Wen-hong and SHI Qing-wen. Historical story on natural medicinal chemistry: Steroids[J]. Chinese Traditional and Herbal Drugs, 2016, 47(8): 1251-1264 |
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| Authors: | GUO Rui-xi LI Li-geng WANG Yu-fang WANG Lei ZHANG Man-li ZHAN Wen-hong SHI Qing-wen |
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| Affiliation: | Department of Medicinal Chemistry, College of Chemical Engineering, Shijiazhuang College, Shijiazhuang 050035, China;Department of Natural Medicinal Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China;Department of Natural Medicinal Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China;Department of Natural Medicinal Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China;Department of Natural Medicinal Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China;Department of Natural Medicinal Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China;Department of Natural Medicinal Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China;Department of Natural Medicinal Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China |
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| Abstract: | Steroids are the most important class of natural products. In the history of the development of human beings, not only steroidal compounds have made the special contribution for human health, but also its special stereochemical structure plays an important role in the development of organic chemistry, especially organic chemistry theory, which could improve the stereochemical theory. In this paper, the discovery, biological activity, the stereochemical structure of important compounds, stereochemistry, and the synthesis of steroids are briefly introduced for the purpose to broaden their horizon and provide some ideas for young teachers in the teaching and scientific research. |
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| Keywords: | steroids steroidal saponins steroid hormone stereostructure stereochemistry synthesis |
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