| D-最优混料设计结合多种力学指标优化柴栀凝胶贴膏的基质处方及其体外释放透皮研究 |
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| 引用本文： | 章烨雯,于竞新,王景雁,茹庆国,刘艳,王逸飞,林红梅,吴清. D-最优混料设计结合多种力学指标优化柴栀凝胶贴膏的基质处方及其体外释放透皮研究[J]. 中国中药杂志, 2016, 41(6): 1046-1053 |
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| 作者姓名： | 章烨雯 于竞新 王景雁 茹庆国 刘艳 王逸飞 林红梅 吴清 |
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| 作者单位： | 北京中医药大学 中药学院, 北京 100102,北京中医药大学 中药学院, 北京 100102,北京中医药大学 中药学院, 北京 100102,北京中医药大学 中药学院, 北京 100102,北京中医药大学 中药学院, 北京 100102,北京中医药大学 中药学院, 北京 100102,北京中医药大学 中药学院, 北京 100102,北京中医药大学 中药学院, 北京 100102 |
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| 基金项目： | 北京中医药大学自主选题项目(2015-JYB-XS102);北京中医药大学创新团队发展计划项目(2011-CXTD-13) |
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| 摘 要： | 该研究旨在优化柴栀凝胶贴膏的基质配方以及评价其体外释放与透皮行为。采用D-最优混料设计,通过探子初黏力试验,180度剥离强度试验和胶强度试验测定凝胶贴膏的黏性指标,包括初黏力,黏接力和内聚力,确定最优基质处方。采用改良Franz扩散池法,以有效成分栀子苷为指标,研究凝胶贴膏的体外释放和经皮渗透性能。柴栀凝胶贴膏的基质配方为NP700,甘羟铝,酒石酸,甘油,PVP K90,蒸馏水(9∶0.7∶0.8∶30∶5∶30.5)。凝胶贴膏中栀子苷24 h体外释放(77.02±3.73)%,经皮渗透速率为7.25μg·cm~(-2)·h~(-1),24 h累积渗透量为(156.22±4.90)μg·cm~(-2)。最优基质处方下制备的柴栀凝胶贴膏具有良好的黏性,栀子苷体外释放符合一级方程,体外透皮接近零级方程。
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| 关 键 词： | D-最优混料设计 黏性指标 凝胶贴膏 体外释放 透皮评价 |
| 收稿时间： | 2015-12-15 |
Matrix formulation of chaizhi cataplasma optimized by D-optimal mixture design combined with multiple mechanical indicators and its in vitro evaluation |
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| ZHANG Ye-wen,YU Jing-xin,WANG Jing-yan,RU Qing-guo,LIU Yan,WANG Yi-fei,LIN Hong-mei and WU Qing. Matrix formulation of chaizhi cataplasma optimized by D-optimal mixture design combined with multiple mechanical indicators and its in vitro evaluation[J]. China Journal of Chinese Materia Medica, 2016, 41(6): 1046-1053 |
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| Authors: | ZHANG Ye-wen YU Jing-xin WANG Jing-yan RU Qing-guo LIU Yan WANG Yi-fei LIN Hong-mei WU Qing |
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| Affiliation: | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China and School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China |
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| Abstract: | |
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| Keywords: | D-optimal mixture design viscosity cataplasma in vitro release transdermal absorption |
| 本文献已被 CNKI 等数据库收录！ |
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