|
|||||
|
|
PHARMACOKINETICS OF MIDAZOLAM IN ANAESTHETIZED CIRRHOTIC PATIENTS |
|
| Authors: | TROUVIN, J.-H. FARINOTTI, R. HABERER, J. P. SERVIN, F. CHAUVIN, M. DUVALDESTIN, P. |
| Affiliation: | Laboratoire de Toxicologie et Département d'Anesthésiologie, Hôpital Bichat F-75018 Paris Centres d'études Phar-maceutiques F-92290 Chatenay Malabry Département d'Anesthésiologie, Hôpital Saint-Jacques F-63003 Clermont-Ferrand Frédérique Ser-vin, m.d., Laboratoire de Toxicologie et Département d'Anesthésiologie, Hôpital Bichat Département d'Anesthésiologie, Hôpital Ambroise-Paré F-92100 Boulogne, France |
| Abstract: | The pharmacokinetics of midazolam were compared in cirrhoticpatients (n = 10) and control patients (n = 9), during generalanaesthesia. Total plasma clearance was 637 ± 223 mlmin1 (mean ± SD) in control patients and 402 ±170 ml min1 in cirrhotic patients (P<0.05). The totalvolume of distribution was similar. Elimination half-life was135 ±40 min in controls and 168±30min in cirrhosis(P<0.05). Protein binding was evaluated by equilibrium dialysisin both groups at two concentrations of midazolam: 20 and 500µg litre1. No saturation occurred, but the freefraction was 4.9±1.7% in cirrhotic patients, comparedwith 1.9±0.6% in controls (P < 0.01). Despite itsmainly hepatic elimination, midazolam disposition appears tobe only slightly impaired in cirrhotic patients. |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ | |