伴有代谢综合征的冠心病患者高敏C反应蛋白浓度的变化

目的探讨伴有代谢综合征(MS)的冠心病患者血清中高敏C反应蛋白(hs-CRP)浓度的变化及其临床意义。方法选择179例冠心病患者为冠心病组,根据冠心病组患者是否伴有MS分为2个亚组,伴MS组(63例)和不伴MS组(116例)。同期选择健康体检者80例为正常对照组。测量身高、体重、血压,测定血糖、血脂和hs-CRP等相关指标,分析血清hs-CRP浓度与冠心病、MS的关系。结果冠心病组患者血清hs-CRP(1.77±0.96)mg/L较正常对照组(1.43±0.51)mg/L明显增高(P<0.05)。伴MS组血清hs-CRP(3.06±1.14)mg/L明显高于正常对照组,且差异有统计学意义(P<0.01);而不伴MS组血清hs-CRP(1.52±0.75)mg/L较正常对照组虽有增高,但差异无统计学意义(P>0.05)。血清hs-CRP浓度随着MS组分数目的增加而增高,且差异有统计学意义(P<0.05)。相关分析表明,血清hs-CRP与体重指数、收缩压、舒张压、TC、空腹血糖呈正相关(r=0.355,0.218,0.312,0.368,0.297,P<0.05),与HDL-C呈负相关(r=-0.221,P<0.05)。结论冠心病患者血清hs-CRP浓度增高,尤其以伴有MS的冠心病患者增高明显。

Changes of plasma high sensitivity C-reactive protein in patients with coronary heart disease and metabolic syndrome

Objective To investigate the change of the plasma high sensitivity C-reactive protein(hs-CRP) and its significance in patients with coronary heart disease(CHD) and metabolic syndrome(MS).Methods 179 patients with definite CHD and 80 normal control subjects were studied.The patients with CHD were divided into two subgroups,namely MS group(n= 63) and non-MS group(n=116),according to the criterion of Chinese Diabetes Society.Plasma hs-CRP,triglyceride(TG),fasting blood glucose(FBG),postprandial blood glucose(PBG),high-density lipoprotein cholesterol(HDL-C),systolic and diastolic blood pressure,body mass index(BMI) were measured.The relationships between hs-CRP and CHD,MS were analyzed.Results The plasma hs-CRP was significantly higher in CHD group(1.77±0.96) mg/L than in control group(1.43±0.51) mg/L,P<0.05.The plasma hs-CRP was significantly higher in CHD+MS group(3.06±1.14) mg/L than in the control group;however,there was no significant difference between non-MS group(1.52±0.75) mg/L and control group(P>0.05).Analyses of results indicated that the plasma hs-CRP was correlated positively with BMI,TG,SBP,DBP and FBG(r=0.355,0.218,0.312,0.368 and 0.297,respecttively,P<0.05),and negatively with HDL-C(r=-0.221,P<0.05).Conclusion The plasma hs-CRP is significantly increased in CHD patients,and especially in CHD+MS group.