S100A4蛋白在乳腺癌中的表达和意义

目的探讨乳腺癌中S100A4的表达及意义。方法采用免疫组织化学SP法检测62例乳腺癌中S100A4表达情况,分析其表达与临床病理特征之间的关系。结果①S100A4表达率在组织学分级Ⅰ级、Ⅱ级、Ⅲ级乳腺癌中分别为45.0%(9/20)、64.0%(16/25)和88.2%(15/17),差异有统计学意义;在淋巴结转移阳性组和阴性组中分别为78.1%(25/32)和50.0%(15/30),差异亦有统计学意义。②S100A4的表达与组织学分级、淋巴结转移呈正相关(P<0.05),然而与年龄、肿瘤大小、TNM分期无显著相关。结论乳腺癌中S100A4的表达与肿瘤的进展密切相关,是判断乳腺癌侵袭、预测转移趋势的有价值的指标。

Expression and Signidicance of S100A4 in Breast Cancer

Objective To discuss the expressions of S100A4 in breast cancer and the significance. Methods The expressions of S100A4 in breast cancer was detected by using immunohistochemistry SP method. Correlation between the expressions and clinicopathological features was analyzed. Results ① The expression of S100A in Ⅰ, Ⅱ, Ⅲ class of the histological grade of breast cancer were 45.0% （9/20）, 64.0% （16/25） and 88.2% （15/17） respectively, and the expression difference had statistics significance; the expression of S100A4 were 78.1% （25/32） and 50.0% （15/30） respectively in positive metastasis of lymph node groups and negative groups,and the difference had statistics significance too. ②Tbe expression of S100A4 had positive correlation with the histological grade and lymph node metastasis （P〈0.05）, however the S100A4 expression and age, tumor size, TNM staging had no significant correlation. Conclusion The expression of S100A4 was significantly associated with tumor progression in breast cancer, which was valuable marker to predict the invasion and trend of metastasis of breast cancer.