|
|||||
|
|
| 前列腺特异性抗原系列在前列腺癌筛选诊断中的价值 | |
| 引用本文： | 杨国胜,陈昭典,刘卫平,彭弋峰. 前列腺特异性抗原系列在前列腺癌筛选诊断中的价值[J]. 华中科技大学学报(医学版), 2004, 33(5): 609-611 |
| 作者姓名： | 杨国胜 陈昭典 刘卫平 彭弋峰 |
| 作者单位： | 1. 浙江大学医学院附属第一医院泌尿外科,杭州,310003 2. 芜湖市第二人民医院泌尿外科,芜湖,241000 3. 皖南医学院生殖医学研究所,芜湖,241001 |
| 摘 要： | 目的 探讨前列腺特异性抗原 (PSA)系列在前列腺癌 (PCa)筛选诊断中的价值。方法 用酶联免疫吸附法测定 6 9例PCa和 2 5 9例良性前列腺增生 (BPH)患者的血清PSA、游离PSA/总PSA (fPSA/tPSA)、PSA速度(PSAV)、PSA密度 (PSAD)和前列腺移行带PSA密度 (PSAT)值。结果 PCa组血清PSAV、PSAD和PSAT的检测值较BPH组明显升高 (P <0 0 1) ,而PSA和fPSA/tPSA两组间无明显差异 (P >0 0 5 )。PSA切变值越高 ,诊断准确性、特异性和阳性预测值越大 ,其中以PSA >10 μg/L时准确性最高。在PCa和BPH鉴别诊断意义上 ,表现为PSAT >PSAD >PSAV >fPSA/tPSA >PSA。结论 检测PSA系列 ,特别是检测PSAT和PSAD ,较单纯检测PSA在PCa筛选诊断中有较高的准确性和特异性。 |
| 关 键 词： | 诊断 PSAD BPH 前列腺癌 PSAT 前列腺特异性抗原 血清PSA 筛选 PC |
| 修稿时间： | 2003-04-10 |
Screening Diagnosis of Prostate Cancer by Prostate-specific Antigen System |
|
| Yang Guosheng,Chen Zhaodian,Liu Weiping et al. Screening Diagnosis of Prostate Cancer by Prostate-specific Antigen System[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2004, 33(5): 609-611 | |
| Authors: | Yang Guosheng Chen Zhaodian Liu Weiping et al |
| Affiliation: | Yang Guosheng1,Chen Zhaodian1,Liu Weiping2 et al 1 Department of Urology,the First Affiliated Hospital of Zhejiang University,Hangzhou 310003 2 Department of Urology,the Second Municipal Hospital of Wuhu,Wuhu 241000 |
| Abstract: | Objective To investigate the value of prostate-specific antigen (PSA) and its system (PSA system) in the screening diagnosis of prostate cancer (PCa).Methods Serum PSA in 69 cases of PCa and 259 cases of benign prostate hyperplasia (BPH) was determinated by Abbot IMX assay and the PSA system such as fPSA/tPSA, PSAV, PSAD and PSAT measured. Results The values of PSAV, PSAD and PSAT in PCa patients were significantly higher than those in BPH (P<0.01), while the values of PSA and fPSA/tPSA between PCa and BPH showed no significant difference (P>0.05). The higher the cutoff value of PSA, the more precision, specificity and positive provisional value of PCa, especially at PSA>10 _g/L. As to the precision, specificity and postive provisional value for PCa among PSA and PSA system, PSAT was the best, followed by PSAD, but PSA was the worst. Conclusion Compared to PSA, PSA system, especially PSAT and PSAD, seems to be more reliable in the screening diagnosis of PCa. |
| Keywords: | prostate neoplasmas prostatic hyperplasia prostate-specific antigen |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |