糖皮质激素短期干预对AECOPD患者清晨空腹皮质醇的影响

目的 研究糖皮质激素短期治疗对AECOPD患者清晨空腹皮质醇的影响。方法 选取38例AECOPD患者随机分为糖皮质激素组（简称激素组）和对照组（非激素组）,检测和比较治疗前后患者血清空腹皮质醇值。结果 治疗后血清空腹皮质醇水平在激素组与对照组两组间比较,差异无统计学意义（P〉0.05）。表明经糖皮质激素短期治疗后,对AECOPD患者血清皮质醇无明显影响。结论 短期小剂量糖皮质激素干预AECOPD患者对下丘脑-垂体肾上-腺皮质（HPA）轴无显著不良影响,为其安全性提供了更多依据。

Influences of the Short-Term treatment With Glucocorticoid on Morning Basal Cortisol Levels in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease

Objective To explore the effects of the short-term therapy with glucocorticoid on morning basal cortisol levels in patients with acute exacerbation chronic obstructive pulmonary disease（ AECOPD） . Methods 38 patients with AECOPD were randomly divided into glucocorticoid group and control group, of which each got 19 patients for this study . The levels of basal cortisol levels in serum were tested and compared by radioimmunoassay before and after the treatment. Results There were no significant differences between two groups in cortisol,so these two groups were comparable. Serum cortisol were reduced in both groups after treatment,However, there were no statistically significant differences between the glucocorticoid group and the control group in basal cortisol（P〉0. 05）. Conclusion The short-term treatment with glucocorticoid had no significant differences on the serum level of basal cortisol between the glucocorticoid group and the control group. The study suggests that short-term treatment with glucocorticoid had no effects on hypothalamic pituitary adrenalcortex（ HPA） , so it is safe in the treatment of AECOPD.