靶控麻醉对直肠癌根治术患者生命体征及免疫功能的影响

目的分析靶控麻醉对直肠癌根治术患者生命体征及免疫功能的影响。方法选取2011年1月-2012年6月间本院收治并接受直肠癌根治术患者26例，对患者麻醉后生命体征及外周血血清白介素6（IL-6），肿瘤坏死因子（TNF-α），调节性T细胞（Tregs）进行分析。结果患者生命体征各指标均有变化，术中与术前、术后1h分别比较差异均有统计学意义（P〈0．05）；血清IL-6、TNF-α浓度术中与术前、术后1h分别比较差异均有统计学意义（P〈0．05）；Tregs表达水平术中较术前明显升高（P〈0．05），术后1h与术中比较差异无统计学意义（P〉0．05）。结论靶控麻醉对患者生命体征具有一定影响，应注意监测术中各项生命指标，以防止并发症发生，对免疫功能有短期影响，但恢复较快，不会造成长期免疫功能降低。

Influence of target controlled infusion on physical sign and immunologic function of patients with radical resection of rectal carcinoma

Objective To explore the influence of target controlled infusion （TCI） on physi- cal sign and immunologic function of the patients with radical resection of rectal carcinoma. Methods Post-anesthetic physical sign, levels of IL-6 and TNF-α and change of Tregs in 26 patients with radical resection of rectal carcinoma were analyzed. Results There were significant differences of every index of physical sign and levels of IL-6 and TNF-α in patients between intraoperative period and preoperative and one hour after operation （P 〈 0.05）. There was significant difference of level of Tregs between intraoperative period and preoperative period（P 〈 0.05）. Conclusion TCI shows a certain influence on physical sign of patients, and each index of physical sign should be monitored carefully in order to avoid the incidence of complications. Meanwhile, it shows a short-term influence on the immune function as well, but depending on rapid recovery, this influence won＇t cause a long-term decline of immune function.