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| 非小细胞肺癌中EML4-ALK融合基因的生物学特性及其治疗 | |
| 引用本文： | 杨彦卓,潘乐康,安广宇.非小细胞肺癌中EML4-ALK融合基因的生物学特性及其治疗[J].肿瘤,2012,32(6):466-470. |
| 作者姓名： | 杨彦卓 潘乐康 安广宇 |
| 作者单位： | 1. 天津医科大学附属肿瘤医院高级病房 天津市肿瘤防治重点实验室,天津,300060 2. 天津医科大学附属肿瘤医院乳腺癌防治研究中心 天津市肿瘤防治重点实验室,天津,300060 3. 首都医科大学附属北京世纪坛医院肿瘤科,北京,100038 |
| 基金项目： | 国家自然科学基金面上项目(编号:81070415) |
| 摘 要： | 在非小细胞肺癌(non-small cell lung cancer,NSCLC)中已发现棘皮动物微管相关蛋白样4(echinoderm microtubule-associated protein-like 4,EML4)和间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)的融合基因.在不吸烟的NSCLC患者中大多可检测出EML4-ALK,其具有独特的病理学特征.EML4-ALK在体内外均有致癌性.ALK抑制剂(crizotinib)在EML4-ALK阳性的NSCLC患者中已取得较好的治疗效果.本综述重点阐述NSCLC中EML4-ALK的生物学特性、临床特征和治疗. |
| 关 键 词： | 癌 非小细胞肺 肿瘤治疗方案 融合基因 EML4-ALK |
Biological characteristics and therapeutic application of EML4-ALK fusion gene in non-small cell lung cancer |
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| YANG Yan-zhuo , PAN Le-kang , AN Guang-yu.Biological characteristics and therapeutic application of EML4-ALK fusion gene in non-small cell lung cancer[J].Tumor,2012,32(6):466-470. | |
| Authors: | YANG Yan-zhuo PAN Le-kang AN Guang-yu |
| Institution: | 1.Department of First-Class Wards,Cancer Hospital of Tianjin Medical University,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China;2.Comprehensive Breast Cancer Center,Cancer Hospital,Tianjin Medical University,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China;3.Department of Oncology,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China |
| Abstract: | The fusion gene between echinoderm EML4(microtubule-associated protein-like 4) and ALK(anaplastic lymphoma kinase) has been identified in non-small cell lung cancer(NSCLC).EML4-ALK is most commonly detected in never smokers with NSCLC and has unique pathologic features.EML4-ALK is oncogenic both in vitro and in vitro.ALK inhibitor(crizotinib) has demonstrated a remarkable clinical efficacy in EML4-ALK-positive NSCLC patients.This review emphasizes the biological and clinical characteristics and the therapeutic application of EML4-ALK in NSCLC. |
| Keywords: | Carcinoma non-small cell lung Antineoplasms protocols Fusion gene EML4-ALK |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |