Influence of Common and Specific HLA-DRB1/DQB1 Haplotypes on Genetic Susceptibilities of Three Distinct Arab Populations to Type 1 Diabetes |
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| Authors: | Mouna Stayoussef Jihen Benmansour Fayza A. Al-Jenaidi Rita Nemr Muhallab E. Ali Touhami Mahjoub Wassim Y. Almawi |
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| Affiliation: | Faculty of Pharmacy, University of Monastir, Monastir, Tunisia,1. College of Medicine and Medical Sciences, Arabian Gulf University,2. Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain,3. Department of Endocrinology, Rizk Hospital, Beirut, Lebanon4. |
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| Abstract: | The contribution of HLA DRB-DQB to type 1 diabetes (T1D) in Bahrainis, Lebanese, and Tunisians was investigated. DRB1*030101-DQB1*0201 was a locus that conferred susceptibility in three populations, while DRB1*040101-DQB1*0302 was a locus that conferred susceptibility only in Tunisians and Bahrainis. The DRB1*100101-DQB1*050101 (Bahrainis) and DRB1*150101-DQB1*060101 (Lebanese) loci were largely protective. The contribution of HLA to T1D must be evaluated with regard to ethnic background. |
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