| 甾体化合物 Ⅺ.Δ1-16-次甲基-11-酮基-17α-羟基副肾皮酮的合成 |
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| 引用本文： | 陈毓群,黄鸣龙.甾体化合物 Ⅺ.Δ1-16-次甲基-11-酮基-17α-羟基副肾皮酮的合成[J].药学学报,1964,11(9):587-590. |
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| 作者姓名： | 陈毓群 黄鸣龙 |
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| 作者单位： | 中国科学院有机化学研究所,上海 |
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| 摘 要： | 本文是说明用较短的新路线合成△1-16-次甲基-11-酮基-17α-羟基副腎皮酮(Ⅵ),即在化合物I中先引进C—11酮基(Ⅲ),再破断16α,17α-氧桥,加入21-乙酰氧基及在C-1脱氢,即得目的物Ⅵ。
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| 收稿时间： | 1963-09-28 |
SYNTHESIS OF 16-METHYLENE PREDNISONE ACETATE |
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| CHEN YUH-CHENG HUANG MIN-LON.SYNTHESIS OF 16-METHYLENE PREDNISONE ACETATE[J].Acta Pharmaceutica Sinica,1964,11(9):587-590. |
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| Authors: | CHEN YUH-CHENG HUANG MIN-LON |
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| Abstract: | An alterative route for the synthesis of 16-methylene prednisone acetate (Ⅵ) is reported. Thus microbiological hydroxylation of 16α-, 17α-epoxide-16β-methyl-△4-pregne-3, 20-dione (I) with Rhizopus nigricans afforded the 11α-hydroxyl compound Ⅱ, which was oxidizied to the 11-keto compound Ⅲ The cleavage of 16α-, 17α-epoxide afforded Ⅳ, which on introduction of C21-acetoxy at and dehydrogenation at C1 yielded the final product Ⅵ. |
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