儿童与成人急性淋巴细胞白血病临床特征的对比观察

目的 分析最近两年来儿童急性淋巴细胞白血病（ＡＬＬ）的临床预后并探讨其免疫学，细胞遗传学特征以及原发性多药耐药的发生率。方法 总结１５４例初治儿童ＡＬＬ的完全缓解（ＣＲ）率，同时动用免疫组织化学、细胞遗传学高等方法对白血病细胞的生物学特征进行研究。结果 儿童初治ＡＬＬ的平均ＣＲ率是９４．１％，显著高于成人（６７．８％）；免疫分型中，同时伴髓系表达者占１８．５％，Ｐｈ染色体的阳性率是４．８％，两组频

Comparative study of clinical features of childhood and adult acute lymphoblastic leukemia

Objective To analyze the outcome,the immunological and cytogenetic characteristics and the frequency of primary multi drug resistance of childhood acute lymphoblastic leukemia(ALL)in our hospital during the past two years.Method The complete remission(CR) rate of 154 newly diagnosed ALL patients were analysed and the biological features of the leukemic cells were explored by immunochemistry and cytogenetics. Results The CR rate in the ALL children is 94.1% which is significantly higher than that of adult ALL patients(67.8%). Immunophenotype analysis showed that 18.5% of the children expressed myeloid antigens besides lymphoid antigens and 4.8% of them were Ph chromosome positive.Both the figures were lower than that of adult patients.Conclusion Childhood ALL has distinct morphological, immunological and cytogenetic (MIC) features,which might contribute to the good prognosis of the patients.