Left Extended Hepatectomy for a Metastatic Gastrointestinal Stromal Tumor After a Disease-Free Interval of 17 Years: Report of a Case |
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Authors: | Lea Matsuoka Maria Stapfer Rod Mateo Nicolas Jabbour Win Naing Rick Selby Singh Gagandeep |
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Institution: | (1) Division of Hepatobiliary/Pancreatic Surgery and Abdominal Organ Transplantation, Keck School of Medicine, University of Southern California, University Hospital, 1510 San Pablo Street, HCC Suite 200, Los Angeles, CA 90033, USA;(2) Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles County Medical Center, Los Angeles, CA 90033, USA |
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Abstract: | Gastrointestinal stromal tumors (GISTs), although rare, are frequently diagnosed with liver metastasis. These metastatic GISTs
are poorly responsive to conventional chemotherapy; however, recent studies report improved survival after complete surgical
resection of liver metastases. On the other hand, few reports describe the treatment of delayed liver metastasis after resection
of a primary GIST. We report the case of a 55-year-old woman found to have liver metastasis from a GIST after a 17-year disease-free
interval. The patient underwent a left extended hepatectomy for a complete resection of the metastatic GIST and is alive and
well 30 months later. To our knowledge, this is the longest disease-free interval reported in the literature, and emphasizes
the importance of considering late metastasis when evaluating patients with a history of GIST. Thus, surgical resection of
delayed liver metastasis from a GIST should be considered as primary therapy. |
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Keywords: | Gastrointestinal stromal tumor Liver metastasis Hepatic resection |
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