Cofilin peptide homologs interfere with immunological synapse formation and T cell activation |
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Authors: | Eibert Sybille M Lee Kyeong-Hee Pipkorn Rüdiger Sester Urban Wabnitz Guido H Giese Thomas Meuer Stefan C Samstag Yvonne |
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Affiliation: | Institute for Immunology, Ruprecht-Karls-University, D-69120 Heidelberg, Germany. |
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Abstract: | The formation of supramolecular activation clusters within the immunological synapse, crucial for sustained signaling and T lymphocyte activation, requires costimulation-dependent reorganization of the actin cytoskeleton. Here we have identified the actin-remodeling protein cofilin as a key player in this process. Cell-permeable peptides that block costimulation-induced cofilin/F-actin interactions in untransformed human T lymphocytes impair receptor capping and immunological synapse formation at the interface between T cells and antigen-presenting cells. As a consequence, T cell activation, as measured by cytokine production and proliferation, is inhibited. |
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