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| 番泻叶提取物的急性毒性实验研究 | |
| 引用本文： | 李荣群,张跃明,余道军,陈汉卿,庄爱文.番泻叶提取物的急性毒性实验研究[J].现代中西医结合杂志,2008,17(6):820-822. |
| 作者姓名： | 李荣群 张跃明 余道军 陈汉卿 庄爱文 |
| 作者单位： | 1. 浙江中医药大学,浙江,杭州310053 2. 浙江省杭州市第一人民医院,浙江,杭州,310006 3. 浙江省中医院,浙江,杭州,310006 |
| 基金项目： | 浙江省教育厅资助课题(06072) |
| 摘 要： | 目的观察番泻叶提取物对小鼠的急性毒性反应。方法预实验初步确定用药剂量,正式实验取60只昆明种小鼠,用药剂量最低700倍,最高1 500倍,连续观察7 d,记录动物反应及死亡情况。结果各剂量组小鼠出现腹泻症状的程度与给药量呈正比,病理切片显示死亡小鼠符合低血容量性休克的病理改变。番泻叶提取物对小鼠急性毒性LD50=185.44 g/kg,相当于正常人用药量的1 112.6倍剂量。结论大量滥用番泻叶对肾、胃肠系统会造成较为严重的损害。 |
| 关 键 词： | 番泻叶 急性毒性 提取物 |
| 文章编号： | 1008-8849(2008)06-0820-03 |
| 修稿时间： | 2007年7月7日 |
Empirical study of acute toxicity on Folium Sennae extractive |
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| Li Rongqun,Zhang Yueming,Yu Daoiun,Chen Hanqing,Zhuang Aiwen.Empirical study of acute toxicity on Folium Sennae extractive[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2008,17(6):820-822. | |
| Authors: | Li Rongqun Zhang Yueming Yu Daoiun Chen Hanqing Zhuang Aiwen |
| Institution: | Li Rongqun1,Zhang Yueming1,Yu Daojun2,Chen Hanqing1,Zhuang Aiwen3 |
| Abstract: | Objective It is to observe the rapid toxicity effect on Folium Sennae extractive.Methods After preliminary experiment to determine the dosage,60 mice were selected and divided into 6 groups,the dosage were 700 multiple to 1 500 multiple.The reaction of mice was observed and recorded in the next 7 days.Results The degree of diarrhoea was different which depend on the dosage.The mouse pathological section showed: the deadly reason is hypovolemic shock.The acute toxicity of Folium Sennae extractive LD50=185.44 g/kg,the multiple was 1 112.6 times of normal.Conclusion Superfluous Folium Sennae can result in serious damage on kidney and digestive system. |
| Keywords: | Folium Sennae acute toxicity extractive |
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