体重指数、脑钠肽前体与不同类型心力衰竭的关系

目的 探讨体重指数（body mass index，BMI）、脑钠肽前体在不同类型的心力衰竭患者中的关系。方法 连续入选心力衰竭患者272名，健康对照组30例，测定其BMI、脑钠肽前体及其他临床资料。结果 射血分数保留的心力衰竭（heart failure of preserve ejection fraction，HF-pEF）组BMI与脑钠肽前体呈中度负相关（r=-0.576，P=0.000），射血分数降低的心力衰竭（heart failure of reduce ejection fraction，HF-rEF）组体重指数与脑钠肽前体呈低度负相关（r=-0.389，P=0.014），HF-rEF组脑钠肽前体的诊断值较HF-pEF组高。结论 HF-pEF体重指数与脑钠肽前体相关性较HF-rEF明显，脑钠肽前体在HF-pEF与HF-rEF中的诊断截点均受BMI影响，在HF-pEF中诊断值较低。

Relationship between Body Mass Index and NT-Pro BNP in Patients with Different Types of Heart Failure

Objective To investigate the relationship between body mass index (BMI) and NT-Pro BNP in patients with different types of heart failure. Methods We selected 272 patients with heart failure treated in Zhongnan Hospital of Wuhan University as case group and 30 healthy subjects as control group consecutively,then measured their BMI,NT-Pro BNP and other clinical data. Results BMI was negatively correlated to NT-Pro BNP in both HF-rEF group and HF-pEF group and this negative correlation was more apparent in HF-pEF group (r=-0.389,P=0.014 for HF-rEF group and r=-0.576,P=0.000 for HF-pEF group, respectively). The diagnostic cutoff point was higher in HF-rEF group than that in HF-pEF group after stratification by BMI. Conclusion The negative correalation between BMI and NT-Pro BNP was more apparent in HF-pEF group than that in HF-rEF group.And the diagnostic cutoff point of NT-Pro BNP was significantly effected by patients'' BMI in both HF-rEF group and HF-pEF group. Moreover, the diagnostic value of NT-Pro BNP was lower in the latter.