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Determination of diosmin in pharmaceutical formulations using Fourier transform infrared spectrophotometry |
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| Authors: | Andrei A Bunaciu Gabriela Elena Udristioiu Lavinia L Ruţă Şerban Fleschin Hassan Y Aboul-Enein |
| Institution: | aCromatec_plus srl, Analytical Research Department, 18 Sos. Cotroceni, Bucharest 6, 060114, Romania;bDepartment of Organic Chemistry, Faculty of Chemistry, University of Bucharest, 92-96, Sos. Panduri, Bucharest-5, 050663, Romania;cPharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, Dokki, Cairo 12311, Egypt |
| Abstract: | A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of diosmin in different pharmaceutical drugs. Conventional KBr-spectra were compared for best determination of active substance in commercial preparations. The Beer–Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing. |
| Keywords: | FT-IR analysis Diosmin Chemometric methods Drug analysis |
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