| 核基质蛋白22在上尿路移行细胞癌诊断中的作用 |
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| 引用本文： | 肖云翔,那彦群,辛殿祺,由然,杨勇,郭应禄. 核基质蛋白22在上尿路移行细胞癌诊断中的作用[J]. 中华泌尿外科杂志, 2002, 23(6): 342-343 |
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| 作者姓名： | 肖云翔 那彦群 辛殿祺 由然 杨勇 郭应禄 |
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| 作者单位： | 100034,北京大学第一医院泌尿外科,北京大学泌尿外科研究所 |
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| 摘 要： | 目的 探讨核基质蛋白 2 2 (NMP 2 2 )在上尿路移行细胞癌诊断中的作用。 方法 对2 4例肾盂癌及输尿管癌患者和 2 0例良性泌尿系疾病患者尿中NMP 2 2浓度及尿细胞学进行检测 ,计算诊断敏感性和特异性。 结果 2 4例TCC患者尿液标本尿细胞学阳性 14例 ,NMP 2 2阳性 2 1例 ;2 0例良性泌尿系疾病患者尿液标本细胞学阳性 1例 ,NMP 2 2阳性 4例 ,NMP 2 2的诊断敏感性和特异性分别为 87.5 %和 80 .0 % ,尿细胞学为 5 8.3%和 95 .0 % ,比较二者敏感性差别有显著性意义。 结论 NMP 2 2可能成为检测上尿路移行细胞癌的良好辅助手段
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| 关 键 词： | 核蛋白类 癌 移行细胞 上尿路 |
| 修稿时间： | 2001-04-13 |
A clinical evaluation of nuclear matrix protein 22 in urine as an adjuvant diagnostic marker for transitional cell carcinoma of the upper urinary tract |
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| XIAO Yunxiang,NA Yanqun,XIN Dianqi,et al.. A clinical evaluation of nuclear matrix protein 22 in urine as an adjuvant diagnostic marker for transitional cell carcinoma of the upper urinary tract[J]. Chinese Journal of Urology, 2002, 23(6): 342-343 |
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| Authors: | XIAO Yunxiang NA Yanqun XIN Dianqi et al. |
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| Affiliation: | XIAO Yunxiang,NA Yanqun,XIN Dianqi,et al.First Hospital,Institute of Urology,Peking University 100034,China |
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| Abstract: | Objective To evaluate urinary nuclear matrix protein(NMP 22) as an adjuvant diagnostic marker for transitional cell carcinoma of the upper urinary tract. Methods 24 patients with transitional cell carcinoma of the upper urinary tract and 20 patients with benign urinary diseass were evaluated with urinary NMP 22(cutoff level 10U/ml) and voided urinary cytology.NMP 22 was determined using a commercial test kit. Results The sensitivity and specificity of NMP 22 were 87.5% and 85.0% respectively whereas these of cytology were 58.3% and 95.0%. Conclusions Urinary NMP 22 might be an useful adjuvant diagnostic marker for transitional carcinoma of the upper urinary tract. |
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| Keywords: | Nucleoproteins Carcinoma transitional cell Upper urinary tract |
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