Enalapril和Captopril对大鼠急性心肌梗塞后血流动力学影响的比较

目的　旨在观察Enalapril和Captopril对心肌梗塞后大鼠血流动力学的影响 ,以探讨左室重构的机制 ,并比较两药的差异。方法　选用大鼠心肌梗塞模型 ,分为假手术组、心肌梗塞组、梗塞给药Enalapril组和梗塞给药Captopril组。梗塞前 3d开始饲以Enalapril和Captopril。 结果　心梗后LVEDP明显增加 ,使用Enalapril和Captopril后LVEDP明显降低 ,亦使MAP、LVSP及±dp/dtmax降低 (P <0 .0 1) ,但用药两组无差异 (P <0 .0 1)。结论　心梗后应用Enalapril和Captopril可改善心功能 ,两药无差异

The Effects of Enalapril and Captopril on Hemodynamics after Acute Myocardial Infarction in Rats

Objective To investigate the mechanism of the left vetricular remodeling after acute myocardial infarction,we examined the effects of 3 weeks treatment with angiotesin converting enzyme inhibitors,Enalapril and Captopril,on hemodynamics in mycardial-infarcted rats.Methods The rats were divided into four groups:SO,sham-operated;MI; MI Enalapril treated.and MI Captopril treated. Results The LVEDP were increased significantly after MI ,after using Enalapril and Captopril, LVEDP were decreased significantly(P<0.01), Enalapril and Captopril had no difference(P<0.01).Conclusion The use of Enalapril and Captopril after MI may improve the cardiac function, Enalapril and Captopril have no difference.