脑梗死与血脂蛋白谱关系的研究及临床意义

目的 探讨血脂蛋白酶谱，即血脂、脂蛋白、载脂蛋白AI、AII、B、CII、CIII、E在脑梗死发病中的作用及临床意义。方法选择脑梗死病人200例。健康对照组150例，采取空腹静脉血测定血脂蛋白谱。结果脑梗死病人1p显著增高，高密度脂蛋白-C、apoAI显著降低、apOAI／apoB比值降低，apOAI、高密度脂蛋白-C、apocII的降低及甘油三脂apocⅢ、低密度脂蛋白-C的升高。逐步回归分析优选风险度指标：脑梗死者选LP。结论脑梗死病人存在着血脂代谢的异常，因此对脑梗死的病人进行血脂干预性治疗是非常必要的。

Study on the Relationships of Cerebral Infarction and Lipoproteins and Its Clinical Significance

Objective A study was performed to determine whether there existed differences in regard to serum lipid lipoprotein and apolipoprotein AI, AII,B,CII,CIII,E in cerebrovascular diseases. Methods 200 patients with cerebral infarction and 150 in the control group were selected to have their serum lipoprotein examined. Lp(a) were analyzed with well stardardized ELISA methods. All the Apo were determimed by immunoturbidimetric methods. Results Patients with cerebral infarction had either levels of TG,apoCIII,LDL-C or low levels of apoAl/apoB, HDL-C,apoCII, increased level of lp(a), decreased level of cerebral infarction. Progressive regression analysis selected lp(a) was the first choice of discriminator for cerebral infarction. Conclusion Patients with cerebral infarction being treated with lipoproteinemic interferent method is necessary for their abnormal lipoproteinemia metabolism.