Enalapril和Captopril对急性心肌梗塞后大鼠心脏形态学影响的比较

目的　旨在观察Enalapril和Captopril对心肌梗塞大鼠心脏形态学的影响 ,比较两药的差异 ,以探讨左室重构的机制。方法　选用大鼠心肌梗塞模型 ,分为假手术组、心肌梗塞组、梗塞给药Enalapril组和梗塞给药Captopril组 ,梗塞前 3天开始饲以Enalapril和Captopril。 结果　心梗后左室重量指数及左室腔半径分别比假手术组增加 10 .4 %和 2 4 .5% ,使用Enalapril和Captopril后左室腔半径降低 13.2 %和 12 .7% ,但两给药组无差异 (P <0 .0 1)。结论　心梗后应用Enalapril和Captopril可减轻左室重构 ,改善心功能 ,两药无差异

Effects of Enalapril and Captopril on Morphology After Acute Myocardial Infarction in Rats

Objective To investigate the mechanism of the left vetricular remodeling after acute myocardial infarction,through observing the effects of 3 weeks' treatment with two angiotesin converting enzyme inhibitors, Enalapril and Captopril,on morphology in myocardial-infarcted rats. Methods The rats were divided into three groups:SO,sham-operated;MI; MI Enalapril treated and MI captopril treated. Enalapril and Captopril were given three days before infarction. Results Enalapril and Captopril had special effects on ventricular geometry in rats with infarction,which resulted in decreasing radius of left ventricular cavity by 13.2% and 12.7% respectively compared with MI rats,but the LV weight/bodyweight and the LV chamber radius had been increased 10.4% and 24.5% respectively in MI campared with SO, MI Enalapril treated and MI captopril treated.There were no differences (P<0.05). Conclusion The use of Enalapril and Captopril after MI may relieve the left ventricular remodeling and improve the cardiac function,and the two angiotesin converting enzyme inhibitors have no differences.