干细胞向卵母细胞样细胞分化研究进展

胚胎干细胞和成体干细胞如骨髓间充质干细胞等在特定的培养条件下可向卵母细胞样细胞分化,但形成的卵母细胞样细胞能否进行减数分裂并进一步生成有受精能力和发育潜能的配子尚不清楚。若能在体外将成体干细胞向有功能的卵母细胞样细胞诱导分化,并通过体外受精的方式生成健康的子代,将为卵子缺乏所致不育女性提供一条新的治疗途径。本文对近年发表的有关干细胞体外向卵母细胞样细胞分化的文献进行综述,以探讨其临床应用的可行性。

Advancement of the oocyte-like cells differentiating from stem cells

Embryonic stem cells and adult stem cells such as bone marrow stem cells under specific culture conditions could be induced and differentiated into oocyte-like cells. But whether the cells could undertake meiosis, develop into gametes and posses fertilization ability are still uncertainty. If the adult stem cells could be differentiated into functional oocytes and finally be used in clinical practice for producing a healthy offspring, a new therapeutic approach for infertile females with lacking of egg would be born. Here, recently published literatures on the oocyte-like cells derivating from stem cells were reviewed in order to explore the possibility of it＇s clinical application.