叶酸调控H型高血压Hcy水平及心血管事件发生的临床观察

目的 研究观察叶酸调控H型高血压患者同型半胱氨酸（Hcy）水平和心血管事件发生概率的影响.方法 选择我院门诊治疗的134例H型高血压患者,均采用常规健康教育及降压治疗,同时加用叶酸调控治疗.所有患者均随访12个月,观察治疗前后患者血清Hcy水平变化及患者心血管事件发生情况.结果 患者治疗后Hcy水平明显下降,与治疗前比较差异有统计学意义.随访12个月,无心血管事件发生,发生率为0％,治疗前、后比较差异无统计学意义（P＞0.05）.结论 对H型高血压患者在常规治疗基础上采用叶酸调控治疗可降低患者Hcy水平,从而减少心血管事件的发生率,提高患者生活质量.

The clinical observation of folic acid on plasma homocysteine and cardiovascular events for patients with hyperhomocysteinima-related hypertention

Objective To evaluate and observe the effect of folic acid on plasma homocysteine and cardiovascular events in patients with hyperhomocysteinima-related hypertention.Methods 134 patients with hyperhomocysteinima-related hypertention were given the routine treatment with antihypertensive drug,in addition to folic acid.All patients were observed three months.Results After folic acid administration treatment for 12 months,the level of homocysteine was significantly decreased compared with the beginning （P＜0.01）.There were none cardiovascular events in the three months in the patients （P＞0.05）.Conclusion The treatment of with folic acid can reduce the level of plasma homocysteine and decreases the rates of cardiovascular events in patients with hyperhomocysteinima-related hypertention.