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Combining H NMR spectroscopy and chemometrics to identify heparin samples that may possess dermatan sulfate (DS) impurities or oversulfated chondroitin sulfate (OSCS) contaminants
Authors:Qingda Zang   David A. Keire   Richard D. Wood   Lucinda F. Buhse   Christine M.V. Moore   Moheb Nasr   Ali Al-Hakim   Michael L. Trehy  William J. Welsh  
Affiliation:a Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine & Dentistry of New Jersey, Piscataway, NJ 08854, USA;b Snowdon, Inc., 1 Deer Park Drive, Suite H-3, Monmouth Junction, NJ 08852, USA;c Department of Health Informatics, School of Health Related Professions, University of Medicine & Dentistry of New Jersey, Newark, NJ 07107, USA;d Food and Drug Administration, CDER, Division of Pharmaceutical Analysis, St Louis, MO 63101, USA;e Food and Drug Administration, CDER, Office of New Drug Quality Assessment, Silver Spring, MD 20993, USA
Abstract:
Keywords:Heparin   Proton nuclear magnetic resonance spectroscopy   Pattern recognition   Principal components analysis   Linear discriminant analysis
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