进入不同治疗方案良性前列腺增生患者客观指标的数据分析

目的 了解进入观察等待、药物治疗和手术治疗3种治疗方案的良性前列腺增生患者的主要客观指标的具体数据,分析其对治疗方案选择的影响.方法 按照试验规定的纳入和排除标准,选择初诊的良性前列腺增生患者329例,按目前泌尿外科的实际诊疗状况,将患者列入观察等待(61例)、药物治疗(179例)和手术治疗(89例)3种治疗方案组,对入组患者的前列腺体积、血清前列腺特异性抗原(PSA)、最大尿流率、平均尿流率,排尿量、残余尿指数等进行观察.结果 观察等待、药物治疗和手术治疗3种治疗方案组患者的前列腺体积(ml)均数为33.0、40.1、65.5;最大尿流率(ml/s)均数为17.1、12.4、9.1;平均尿流率(ml/s)均数为9.9、7.3、4.2;排尿量(ml)均数为332、247、188.以上指标组间差异具有统计学意义.血清前列腺特异性抗原(ng/ml)均数为1.53、1.99、5.44;残余尿量(ml)均数为21、45、208.这2种指标手术治疗组与其他2组间差异具有统计学意义,而在药物治疗和观察等待组间差异无统计学意义.结论 前列腺体积、血清前列腺特异性抗原(PSA)、最大尿流率、平均尿流率、排尿量、残余尿是良性前列腺增生症患者选择治疗方案的重要影响因素.

Data analysis of the objective observation parameters of benign prostatic hyperplasia patients accepting different treatment regimens

Objective To observe different objective observation parameters of the benign prostatic hyperplasia(BPH)patients accepting different treatment strategies,and to further analyze the relationship of these factors with the treatment option．Methods Three hundred and twenty-nine BPH patients,aged 50-80,were assigned into 3 groups jointly decided by the physicians and patients based on the individual conditions and the patients'willingness:watchful waiting group(n=61),aged(63±8),drug treatment group(n=179),aged(68±7),and operation group(n=89),aged(71±6).The data of prostate volume,prostate specific antigen(PSA),maximum flow rate(Qmax),average flow rate,urinating volume,and residual urine volume before treatment were recorded.Results The prostate volume of the watchful waiting group was 33.0 ml,significantly smaller then those of the drug treatment and operation groups(40.1 and 65.5 ml respectively,both P<0.01);the Qmax of the watchful waiting group was 17.1 ml/s,significantly higher than those of the drug treatment and operation groups(12.4 and 9.1 ml/s respectively,both P<0.01).and the urinating volume of the watchful waiting group was 332 ml,significantly more than those of the drug treatment and operation groups(247 and 188 ml respectively,both P<0.01).The serum PSA of the operation group Was 5.44 ng/ml,significantly higher than those of the watchful waiting and drug treatment groups(1.53 and 1.99 ng/ml respectively,both P<0.01):and the residual urine volume of the operation group was 208 ml,significantly higher than those of the watchful waiting and drug treatment groups(21 and 45 ml respectively,both P<0.01).There were no significant differences in the serum PSA and residual urine volume between the drug treatment and watchful waiting groups.Conclusions Prostate volume,PSA,Qmax,average flow rate,urinating volume,and residual urine volume are important influential factors influencing the treatment option of BPH．Data analysis of the objective observation parameters will be helpful in clinical decision making.