| 女性肺癌组织中细胞周期蛋白E的表达 |
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| 引用本文： | 秦怡,何钦成,关鹏,周宝森. 女性肺癌组织中细胞周期蛋白E的表达[J]. 中国公共卫生, 2003, 19(7): 807-808 |
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| 作者姓名： | 秦怡 何钦成 关鹏 周宝森 |
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| 作者单位： | 1. 辽宁省疾病预防控制中心,沈阳,110005
2. 中国医科大学流行病教研室 |
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| 基金项目： | 美国中华医学会医学基金资助 |
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| 摘 要： | 目的 研究细胞周期蛋白E在女性肺癌组织中的表达及意义。方法 采用链菌素亲生物素 -过氧化酶免疫组化方法。结果 女性肺癌组织中细胞周期素E的表达占 62 % ,癌旁正常组织中阳性率占 2 6 % ,二者相比有显著性差异 (P <0 0 5) ,同时鳞癌中细胞周期素E的阳性略要高于腺癌。但细胞周期素E的表达与临床分期及分化无关。结论 女性肺癌组织中存在细胞周期素E的过表达 ,提示细胞周期素E有可能是肺癌的潜在预报因子
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| 关 键 词： | 肺癌 细胞周期素E 免疫组织化学 |
| 文章编号： | 1001-0580(2003)07-0807-02 |
| 修稿时间： | 2002-11-19 |
Expression of cyclin E in female lung cancer |
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| QIN Yi,HE Qin cheng,GUAN Peng,et al.. Expression of cyclin E in female lung cancer[J]. Chinese Journal of Public Health, 2003, 19(7): 807-808 |
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| Authors: | QIN Yi HE Qin cheng GUAN Peng et al. |
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| Affiliation: | QIN Yi,HE Qin cheng,GUAN Peng,et al.Liaoning Center for Disease Control and Prevantion |
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| Abstract: | Objective To investigate the expression and significance of cyclin E in female lung cancer.Methods Using s-p immunohistochemical analysis.Results Thirty-one cases of female lung cancer (31/50, 62%) showed overexpression of cyclin E, and thirteen cases of normal tissues (13/50,26%) were positive for cyclin E.Overexpression of cyclin E was more frequently observed in squamous cell carcinoma compared with that in adenocarcinoma,but without statistically significant.And there were independent histological types or grade of tumor.Conclusion There were overexpression of cyclin E in female lung cancer,which indicated that cyclin E may be a prognostic role in lung caner tissue. |
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| Keywords: | lung cancer cyclin E immunohistochemical |
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