脂化前列腺素E1治疗糖尿病足疗效观察

目的　观察脂化前列腺素E1(Lipo PGE1)对糖尿病足 (DF)的治疗作用。　方法　选择DF患者 12 0例 ,分为Lipo PGE1治疗组和对照组 ,均以饮食控制及应用胰岛素 (Ins)控制血糖。治疗组则增加Lipo PGE1治疗 ,共 3周。对照组加罂粟碱治疗 3周。观察两组治疗前后足部病变改善、代谢紊乱、足背动脉内径、血流速度、尿白蛋白定量 (UAE)等的变化及治疗过程中出现的副作用。　结果　治疗组总有效率显著高于对照组 (P <0 0 1) ,治疗组Wagner分级Ⅱ～Ⅳ级患者有效率显著增高(P <0 0 5 )。两组患者治疗后UAE水平均显著下降 (P <0 0 5 ) ,治疗组上述各指标改善也明显优于对照组 (P <0 0 5 )。Lipo PGE1治疗过程中无严重副作用发生。　结论　Lipo PGE1通过改善足部的微循环和营养代谢而有效地改善DF患者的足部症状 ,加速溃疡愈合

Effects of lipo-prostaglandin E1 on patients with diabetic foot

Objective To investigate the effects of lipo -p rostaglandin E 1 on patients with diabetic foot. Methods 1 20 patients with diabetic foot were divided into control group (40 cases, regula r therapy papaverin) and treatment group (80 cases,regular therapy lipo-pros taglandin E 1). The course of treatment was 3 weeks .Before and after treatme nt, the inner diamenter of dorsal pedal artery and blood current velocity o f lower extremity were measured by Doppler. Urinary albumin excretion rate (UAER), low density cholesterol, and triglyceride were determined respectively. Results Total validity rate was higher in treatment group (P<0.01). After 3 weeks treatment, the UAER of both groups were decreased significantly(P<0.05), while UAER of treatment group was significantly more decreased compared with control group.The inner diamenter of dorsal pedal artery and blood current velocity of lower extremity were not improved signific antly in both groups. No severe side-effects were found during the study. Conclusion Treatment with lipo-prostaglandin E 1 may effect ively ameliorate the coolness,numbness and pain in the lower extremities and pro mote healing of foot ulcer in diabetic patients.